体重与前列腺癌：一项前瞻性研究。
Body mass and prostatic cancer: a prospective study.
作者信息
Severson R K, Grove J S, Nomura A M, Stemmermann G N
机构信息
Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu 96817.
出版信息
BMJ. 1988 Sep 17;297(6650):713-5. doi: 10.1136/bmj.297.6650.713.
Previous studies have suggested that increased body mass is associated with an increased risk of prostatic cancer, but these studies have been limited by the fact that they were based on a few simple measurements such as height and weight. Similar results were found in a prospective study of the incidence of prostatic cancer in a cohort of Japanese men born in 1900-19 and living in Hawaii. Further evaluation of the extensive anthropomorphic measurements made in this cohort suggested that the association between measures of body mass and prostatic cancer might be accounted for more by lean tissue than by fat tissue. There was a significant positive association of the risk of prostatic cancer with area of muscle in the arm but not with area of fat in the arm. Further research is needed on the biological mechanisms of carcinogenesis that may be related to both lean and fat tissue and the development of prostatic cancer.
以往的研究表明，体重增加与前列腺癌风险增加有关，但这些研究存在局限性，因为它们是基于身高和体重等一些简单测量得出的。在一项对1900年至1919年出生并居住在夏威夷的日本男性队列中前列腺癌发病率的前瞻性研究中也发现了类似结果。对该队列中进行的广泛人体测量的进一步评估表明，体重测量与前列腺癌之间的关联可能更多地由瘦组织而非脂肪组织导致。前列腺癌风险与手臂肌肉面积呈显著正相关，而与手臂脂肪面积无关。需要进一步研究可能与瘦组织和脂肪组织以及前列腺癌发生都相关的致癌生物学机制。
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