Davoodi Sayed Hossain, Malek-Shahabi Talieh, Malekshahi-Moghadam Ali, Shahbazi Roghieh, Esmaeili Saeideh
Dept. of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences, Food Science and Technology, Shahid Beheshti University of Medical Sciences,Tehran, Iran.
Dept. of Molecular genetics, Shahid Beheshti University, Tehran, Iran.
Iran J Cancer Prev. 2013 Fall;6(4):186-94.
Cancer could be described as the uncontrolled and unrestricted growth of malignant cells in any place of the body. It is a multifactorial disease which either heredity or environmental factors (such as nutrition, physical inactivity, alcohol, obesity, exposure to sun, environmental pollutants, infections) chip in incidence of cancer. In recent years, several researchers have focused on obesity as a potent cancer risk factor. Scientificevidences have suggested that obesity has associated with increased risk for a plenty of different types of cancer. The evidences are the most consistent for endometrial cancer, breast cancer between the postmenopausal women, and renal cell cancer. More contradictoryresults have reported about the colorectal, prostate, and pancreatic cancer. Although numerous studies have done according to the obesity and cancer relation or joint, but the molecular mechanisms in which obesity could increase the risks of cancer, have been poorly understood.
癌症可以被描述为身体任何部位恶性细胞的不受控制和无限制的生长。它是一种多因素疾病,遗传或环境因素(如营养、缺乏运动、酒精、肥胖、日晒、环境污染物、感染)都会影响癌症的发病率。近年来,一些研究人员将重点放在肥胖作为一种强大的癌症风险因素上。科学证据表明,肥胖与多种不同类型癌症的风险增加有关。这些证据在内膜癌、绝经后女性的乳腺癌和肾细胞癌方面最为一致。关于结直肠癌、前列腺癌和胰腺癌的报道则更具矛盾性。尽管已经针对肥胖与癌症的关系或关联进行了大量研究,但肥胖增加癌症风险的分子机制仍知之甚少。