成年海马神经元在海马记忆干扰和标记中的功能。
Functions of adult-born neurons in hippocampal memory interference and indexing.
机构信息
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
出版信息
Nat Neurosci. 2019 Oct;22(10):1565-1575. doi: 10.1038/s41593-019-0484-2. Epub 2019 Sep 2.
Abstract
The dentate gyrus-CA3 circuit of the hippocampus is continuously modified by the integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged period of maturation, during which they exhibit heightened synaptic plasticity and refinement of electrophysiological properties and connectivity. Consistent with theoretical models and the known functions of the dentate gyrus-CA3 circuit, acute or chronic manipulations of abDGCs support a role for abDGCs in the regulation of memory interference. In this Review, we integrate insights from studies that examine the maturation of abDGCs and their integration into the circuit with network mechanisms that support memory discrimination, consolidation and clearance. We propose that adult hippocampal neurogenesis enables the generation of a library of experiences, each registered in mature abDGC physiology and connectivity. Mature abDGCs recruit inhibitory microcircuits to support pattern separation and memory indexing.
摘要
海马齿状回-CA3 回路不断被成年新生的齿状回颗粒细胞（abDGCs）的整合所改变。所有 abDGCs 都经历一个漫长的成熟过程，在此期间，它们表现出更高的突触可塑性以及电生理特性和连接的精细调整。与理论模型和已知的齿状回-CA3 回路功能一致，abDGC 的急性或慢性操作支持 abDGC 在调节记忆干扰中的作用。在这篇综述中，我们整合了研究 abDGC 成熟及其整合到支持记忆辨别、巩固和清除的网络机制的见解。我们提出，成年海马神经发生使能够产生一系列经验，每一个经验都在成熟的 abDGC 生理学和连接中记录下来。成熟的 abDGCs 招募抑制性微电路以支持模式分离和记忆索引。
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Science. 2019 May 10;364(6440):578-583. doi: 10.1126/science.aat8789. Epub 2019 May 9.
2
A neural signature of pattern separation in the monkey hippocampus.猴脑中模式分离的神经特征。
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9634-9643. doi: 10.1073/pnas.1900804116. Epub 2019 Apr 22.
3
Distinct hippocampal engrams control extinction and relapse of fear memory.不同的海马记忆印痕控制恐惧记忆的消退和复发。
Nat Neurosci. 2019 May;22(5):753-761. doi: 10.1038/s41593-019-0361-z. Epub 2019 Apr 1.
4
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease.成人海马神经发生在神经健康的个体中较为丰富，而在阿尔茨海默病患者中则急剧下降。
Nat Med. 2019 Apr;25(4):554-560. doi: 10.1038/s41591-019-0375-9. Epub 2019 Mar 25.
5
Re-evaluating Circuit Mechanisms Underlying Pattern Separation.重新评估模式分离的电路机制。
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6
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Science. 2018 Nov 23;362(6417):945-949. doi: 10.1126/science.aau4940.
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8
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10
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