Day R E, Schutt W H
Arch Dis Child. 1979 Jul;54(7):512-7. doi: 10.1136/adc.54.7.512.
Fifteen normal children with large heads (circumference greater than 0.5 cm above the 98th centile) were studied. CAT scans were pefrormed to exclude hydrocephalus, and ventricular size was compared with that of hydrocephalic children. In 11 of the 13 families in which the parents' heads were measured, one parent (10 fathers and one mother) was found to have a large head, as had 6 of 17 siblings. Head circumference at birth was large in 7 of 10 babies and rate of head growth was excessive in 8 of 13. Skull x-ray showed suture diastasis in 7 infants. These families have a benign familial megalencephaly. It is important to recognise this so as to avoid unnecessary investigation and anxiety about normal children with large heads.
对15名头部较大（头围大于第98百分位数0.5厘米以上）的正常儿童进行了研究。进行了计算机断层扫描（CAT）以排除脑积水，并将脑室大小与脑积水儿童的脑室大小进行比较。在测量了父母头部的13个家庭中的11个家庭中，发现一方父母（10名父亲和1名母亲）头部较大，17名兄弟姐妹中有6名也是如此。10名婴儿中有7名出生时头围较大，13名中有8名头部生长速度过快。颅骨X线检查显示7名婴儿有颅骨缝分离。这些家庭患有良性家族性巨脑症。认识到这一点很重要，以便避免对头部较大的正常儿童进行不必要的检查和焦虑。
