来源于共生真菌 TA26-15 的珊瑚衍生真菌 Sordarin 二萜糖苷类化合物，具有一个罕见的 1,3-二氧戊环-4-酮环。

Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-one Ring from the Zoanthid-Derived Fungus TA26-15.

机构信息

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , People's Republic of China.

Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao 266237 , People's Republic of China.

出版信息

J Nat Prod. 2019 Sep 27;82(9):2477-2482. doi: 10.1021/acs.jnatprod.9b00164. Epub 2019 Sep 3.

DOI:10.1021/acs.jnatprod.9b00164

PMID:31478377

Abstract

Six new sordarin tetracyclic diterpene glycosides, moriniafungins B-G (-), and a new sordaricin tetracyclic diterpene, sordaricin B (), together with two known analogues, moriniafungin () and sordaricin (), were isolated from the zoanthid-derived fungus TA26-15. The structures of the new compounds were elucidated by comprehensive analyses of spectroscopic data, including 1D and 2D NMR and MS data. Compounds - represent the first case of sordarins from marine-derived fungi possessing a sordarose with a spiro 1,3-dioxolan-4-one ring, which is rare in the nature. Compound showed antifungal activity against ATCC10231 with an MIC value of 2.9 μM.

摘要

从珊瑚来源的真菌 TA26-15 中分离得到了 6 种新的蛇菰烷四环二萜糖苷，即 moriniafungins B-G(-)，以及一种新的蛇菰烷四环二萜，即 sordaricin B()，此外还有两种已知的类似物，moriniafungin()和 sordaricin()。通过综合分析包括 1D 和 2D NMR 和 MS 数据在内的光谱数据，阐明了这些新化合物的结构。化合物 - 代表了海洋来源真菌中的蛇菰烷类化合物的首例，它们具有带有螺 1,3-二氧戊环-4-酮环的蛇菰糖，这在自然界中很少见。化合物对 ATCC10231 显示出抗真菌活性，MIC 值为 2.9 μM。