Niu Siwen, Fan Zuo-Wang, Xie Chun-Lan, Liu Qingmei, Luo Zhu-Hua, Liu Guangming, Yang Xian-Wen
State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, State Oceanic Administration , 184 Daxue Road, Xiamen 361005, People's Republic of China.
College of Food and Biological Engineering, Jimei University , 43 Yindou Road, Xiamen 361021, People's Republic of China.
J Nat Prod. 2017 Jul 28;80(7):2174-2177. doi: 10.1021/acs.jnatprod.7b00475. Epub 2017 Jul 10.
A novel spiro-tetracyclic diterpene, spirograterpene A (1), was isolated from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, together with two biosynthetically related cyclopianes, conidiogenone I (2) and conidiogenone C (3). The relative configuration of 1 was elucidated by extensive spectroscopic analyses, and the absolute structure was established by the modified Mosher's method. Compound 1 is the second example of a diterpene featuring a 5/5/5/5 spirocyclic carbon skeleton. It showed modest antiallergic activity.
从深海来源的真菌颗粒青霉MCCC 3A00475中分离出一种新型螺环四环二萜类化合物——螺环颗粒萜烯A（1），以及两种生物合成相关的环戊烷类化合物——分生孢子原酮I（2）和分生孢子原酮C（3）。通过广泛的光谱分析阐明了1的相对构型，并通过改良的莫舍尔方法确定了其绝对结构。化合物1是具有5/5/5/5螺环碳骨架的二萜类化合物的第二个实例。它表现出适度的抗过敏活性。
