Zhang Lin, Li Debao, Chen Xuan, Zhao Feng
School of Pharmacy, Yantai University, Yantai 264005, China.
Department of Pharmaceutical and Bioengineering, Zibo Vocational Institute, Zibo 255314, China.
Mar Drugs. 2025 Feb 7;23(2):72. doi: 10.3390/md23020072.
Marine diterpenes are an important category of secondary metabolites derived from marine sources, found in a variety of marine animals, plants, and fungi. The increasing diversity of diterpene compounds, along with their unique chemical structures and specific biological activities, have attracted widespread attention. These activities include anti-inflammatory, antiviral, antitumor, antibacterial effects, and therapeutic actions against cancer, with many already developed into clinical drugs. Additionally, as marine medicinal resources continue to be exploited over the long term, the natural resources of many marine diterpene compounds are diminishing, and the biosynthesis of key active components has become a hot topic of research. In this review, we summarize diterpene compounds discovered in the ocean over the past five years, reclassify these compounds, and summarize their structures, biological activities, biosynthesis, and potential applications of marine diterpenoids from 2019 to 2024. This review can provide a reference for the basic research and potential applications of marine-derived diterpene compounds.
海洋二萜是一类重要的源自海洋的次生代谢产物，存在于多种海洋动物、植物和真菌中。二萜化合物的多样性不断增加，其独特的化学结构和特定的生物活性引起了广泛关注。这些活性包括抗炎、抗病毒、抗肿瘤、抗菌作用以及对癌症的治疗作用，许多已开发成临床药物。此外，随着海洋药用资源长期持续被开发利用，许多海洋二萜化合物的自然资源正在减少，关键活性成分的生物合成已成为研究热点。在本综述中，我们总结了过去五年在海洋中发现的二萜化合物，对这些化合物进行重新分类，并概述了2019年至2024年海洋二萜类化合物的结构、生物活性、生物合成及潜在应用。本综述可为海洋来源二萜化合物的基础研究和潜在应用提供参考。
