School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, China.
School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, China.
Int J Biol Macromol. 2019 Dec 1;141:108-116. doi: 10.1016/j.ijbiomac.2019.08.258. Epub 2019 Aug 31.
Natural protein hydrogels are considered as the promising candidates for biomaterials. However, natural protein hydrogels often exhibit poor mechanical properties. Herein, using bovine serum albumin (BSA) as natural protein model, a new kind of D/C-hybrid DN gels, consisting of tetrakis(hydroxymethyl)phosphonium chloride (THPC) cross-linked BSA (THPC-BSA) as dynamic covalent bond cross-linked first network and covalently cross-linked polyacrylamide (PAAm) as second network, were successfully synthesized by a facile method. Different from fully chemical DN gels without recovery, the optimized THPC-BSA/PAAm D/C-hybrid DN gel not only demonstrated excellent tensile properties, but also displayed extremely fast self-recovery property and fatigue resistance. More importantly, various natural proteins could be also used to prepare natural protein-based D/C-hybrid DN gels, and all of them showed improved mechanical properties and fast self-recovery properties. The results indicate our new strategy to fabricate recoverable natural protein-based D/C-hybrid DN gels is general. We hope our new strategy as well as our natural protein-based D/C-hybrid DN gels will provide a new avenue to prepare and study high performance natural protein hydrogels.
天然蛋白质水凝胶被认为是有前途的生物材料候选物。然而，天然蛋白质水凝胶通常表现出较差的机械性能。在此，我们以牛血清白蛋白（BSA）为天然蛋白质模型，通过一种简便的方法成功合成了一种新型的 D/C 杂化 DN 凝胶，该凝胶由四羟甲基氯化鏻（THPC）交联的 BSA（THPC-BSA）作为动态共价键交联的第一网络和共价交联的聚丙烯酰胺（PAAm）作为第二网络组成。与没有恢复能力的完全化学 DN 凝胶不同，优化后的 THPC-BSA/PAAm D/C 杂化 DN 凝胶不仅表现出优异的拉伸性能，而且还表现出极快的自恢复性能和耐疲劳性。更重要的是，各种天然蛋白质也可用于制备天然蛋白质基 D/C 杂化 DN 凝胶，所有这些都表现出改善的机械性能和快速的自恢复性能。结果表明，我们制备可恢复的天然蛋白质基 D/C 杂化 DN 凝胶的新策略具有通用性。我们希望我们的新策略以及我们的天然蛋白质基 D/C 杂化 DN 凝胶将为制备和研究高性能天然蛋白质水凝胶提供新途径。
