College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, PR China.
College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, PR China.
Carbohydr Polym. 2019 Dec 1;225:115160. doi: 10.1016/j.carbpol.2019.115160. Epub 2019 Aug 8.
Hydrogels with good mechanical properties are promising for various applications. In this work, a simple yet effective method for preparing a novel double-network hydrogel was reported. First, nonfouling polymer, poly(N-(2-hydroxyethyl)acrylamide) (PHEAA), was crosslinked through covalent bonds. Antibacterial polysaccharide, chitosan (CS), was then crosslinked by chelation between the N-glucosamine units on the CS and citrate or sulfate ions. The poly(N-(2-hydroxyethyl)acrylamide)/chitosan double-network hydrogels (PHEAA/CS DN hydrogels) exhibited high tensile strength (3.8 MPa), strong elastic modulus (0.6 MPa). And the dynamic ionic crosslinking in CS network provided the DN gels with fast self-recovery ability as well as excellent fatigue resistance. Furthermore, the mechanical properties of the DN gels were enhanced after stretching and relaxing because of the molecular orientation and reconstruction of chitosan network. More importantly, the hydrogels have excellent antifouling and antibacterial properties, which is called "repelling and killing", making them competitive candidates for applications in the biomedical field.
具有良好机械性能的水凝胶在各种应用中具有广阔的前景。在这项工作中，报道了一种简单而有效的制备新型双网络水凝胶的方法。首先，通过共价键交联非缠结聚合物聚（N-（2-羟乙基）丙烯酰胺）（PHEAA）。然后，通过壳聚糖（CS）上的 N-葡萄糖胺单元与柠檬酸盐或硫酸盐离子之间的螯合作用交联抗菌多糖壳聚糖。聚（N-（2-羟乙基）丙烯酰胺）/壳聚糖双网络水凝胶（PHEAA/CS DN 水凝胶）表现出高拉伸强度（3.8 MPa）、强弹性模量（0.6 MPa）。并且 CS 网络中的动态离子交联赋予了 DN 凝胶快速的自恢复能力以及优异的耐疲劳性。此外，由于壳聚糖网络的分子取向和重构，DN 凝胶在拉伸和松弛后其机械性能得到增强。更重要的是，水凝胶具有优异的抗污和抗菌性能，这被称为“排斥和杀灭”，使其成为在生物医学领域应用的有竞争力的候选者。
