Finocchiaro L M, Arzt E S, Fernández-Castelo S, Criscuolo M, Finkielman S, Nahmod V E
Consejo Nacional de Investigaciones Cientificas y Technicas (C.O.N.I.C.E.T.), República Argentina.
J Interferon Res. 1988 Dec;8(6):705-16. doi: 10.1089/jir.1988.8.705.
Serotonin and melatonin inhibit phytohemagglutinin- (PHA) induced interferon-gamma (IFN-gamma) production by lymphocytes. In this paper, it is shown that IFN-gamma-increased tryptophan uptake by lymphocytes and macrophages led to an enhanced production of serotonin. When IFN-gamma and serotonin were added together to a lymphocyte culture, N-acetyl serotonin and melatonin production was increased, whereas the path to 5-hydroxy-indoleacetic acid remained unchanged. Therefore, the stimulated IFN-gamma production of serotonin and melatonin by lymphocytes and macrophages and the inhibition of IFN-gamma synthesis by these indoleamines suggest a hypothesis for an immunoregulatory circuit.
血清素和褪黑素可抑制植物血凝素（PHA）诱导的淋巴细胞产生γ干扰素（IFN-γ）。本文表明，IFN-γ增加淋巴细胞和巨噬细胞对色氨酸的摄取，从而导致血清素生成增加。当将IFN-γ和血清素一起添加到淋巴细胞培养物中时，N-乙酰血清素和褪黑素的生成增加，而通往5-羟基吲哚乙酸的途径保持不变。因此，淋巴细胞和巨噬细胞对血清素和褪黑素的刺激产生IFN-γ以及这些吲哚胺对IFN-γ合成的抑制作用提示了一种免疫调节回路的假说。
