Gajdács Márió, Urbán Edit, Terhes Gabriella
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Eötvös utca 6., Hungary.
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Semmelweis utca 6., Hungary.
Dent J (Basel). 2019 Sep 1;7(3):85. doi: 10.3390/dj7030085.
Similarly to other non-spore-forming Gram-positive anaerobes, members of the genus are important saprophytic constituents of the normal microbiota of humans. infections are considered to be rare, with cervicofacial infections (also known as 'lumpy jaw syndrome') being the most prevalent type in the clinical practice. Actinomycoses are characterized by a slowly progressing (indolent) infection, with non-specific symptoms, and additionally, the clinical presentation of the signs/symptoms can mimic other pathologies, such as solid tumors, active infections, nocardiosis, fungal infections, infarctions, and so on. The clinical diagnosis of actinomycosis may be difficult due to its non-specific symptoms and the fastidious, slow-growing nature of the pathogens, requiring an anaerobic atmosphere for primary isolation. Based on 111 references, the aim of this review is to summarize current advances regarding the clinical features, diagnostics, and therapy of cervicofacial infections and act as a paper for dentistry specialists, other physicians, and clinical microbiologists.
与其他非芽孢形成革兰氏阳性厌氧菌类似，该属成员是人类正常微生物群的重要腐生成分。放线菌感染被认为很罕见，在临床实践中，颈面部感染（也称为“肿块性颌骨综合征”）是最常见的类型。放线菌病的特征是感染进展缓慢（隐匿性），伴有非特异性症状，此外，体征/症状的临床表现可模仿其他疾病，如实体瘤、活动性感染、诺卡菌病、真菌感染、梗死等。由于放线菌病症状不具特异性，且病原体苛求、生长缓慢，需要厌氧环境进行初次分离，因此其临床诊断可能较为困难。基于111篇参考文献，本综述的目的是总结颈面部感染在临床特征、诊断和治疗方面的当前进展，并为牙科专家、其他医生和临床微生物学家提供参考。
