Secalim, INRA, Oniris, Université Bretagne Loire, 44307, Nantes, France.
Service de nutrition et gastroentérologie pédiatriques, hôpital Trousseau, Sorbonne Université, AP-HP, Paris, France.
Nutrients. 2019 Sep 1;11(9):2045. doi: 10.3390/nu11092045.
Dietary iron deficiency (ID) is the first nutritional deficiency in the world, in terms of disability adjusted life years (DALY). This nutritional deficiency may lead to anemia, especially among children, adolescents, and adult women. The aim of this study was to build an original probabilistic model to quantitatively assess the ID, the iron deficiency anemia (IDA) and the subsequent health burden in France expressed in DALY, per age class and gender. The model considered the distribution of absorbed iron intake, the iron requirement distribution established by the European Food Safety Authority and the iron status in France. Uncertainty due to lack of data and variability due to biological diversity were taken into account and separated using a second-order Monte Carlo procedure. A total of 1290 (95% CI = 1230-1350) IDA cases corresponding to 16 (95% CI = 11-20) DALY were estimated per 100,000 individuals per year. The major contributors to IDA burden were menstruating females aged from 25 to 44 years old. Then, a consumption scenario was built with ground beef as intake, an increase in red meat consumption to 100 g/d would not eliminate entirely the IDA burden. The quantitative methodology applied here for France could be reused for other populations.
膳食铁缺乏（ID）是全球第一个因残疾调整生命年（DALY）导致的营养缺乏症。这种营养缺乏可能导致贫血，尤其是儿童、青少年和成年女性。本研究旨在构建一个原创的概率模型，以定量评估法国的 ID、缺铁性贫血（IDA）以及随之而来的健康负担，以 DALY 表示，按年龄组和性别分类。该模型考虑了吸收铁摄入量的分布、欧洲食品安全局确定的铁需求量分布以及法国的铁状况。考虑到数据缺乏和生物多样性的变异性，使用二阶蒙特卡罗程序进行了分离。每年每 10 万人中估计有 1290 例（95%CI=1230-1350）IDA 病例，相当于 16（95%CI=11-20）个 DALY。导致 IDA 负担的主要因素是 25 至 44 岁的经期女性。然后，构建了一个以牛肉为摄入物的消费情景，如果将红肉的摄入量增加到 100 克/天，也不会完全消除 IDA 负担。这里为法国应用的定量方法可用于其他人群。
