Suppr超能文献

法国红肉的公共卫生风险-效益评估:当前消费与替代情景。

Public health risk-benefit assessment of red meat in France: Current consumption and alternative scenarios.

机构信息

INRAE, Oniris, SECALIM, 44307, Nantes, France.

Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31300, Toulouse, France.

出版信息

Food Chem Toxicol. 2021 Mar;149:111994. doi: 10.1016/j.fct.2021.111994. Epub 2021 Jan 21.

Abstract

Consumption of red meat has been associated with the risks of colorectal cancer (CRC), cardiovascular disease (CVD), foodborne-pathogen related diseases and with the potential benefit obtained by reduction of iron deficiency anemia (IDA). Based on probabilistic models, current risks and benefit for the French population were aggregated into a single metric, the disability adjusted life years (DALY). In France, per 100,000 people, current red meat consumption was responsible for a mean of 19 DALYs due to CRC, 21 DALYs to CVD and 7 DALYs to foodborne diseases. Current consumption of iron throughout the diet led to a mean of 15 DALYs due to IDA. To mitigate the risks, scenarios were built per sub-population of age and gender. Among adult and elderly population, the big meat eaters would benefit to adhere to the current recommendation (less than 500 g/w): the risks of CRC and CVD would decrease. Regarding IDA (scenario built with fixed ground beef amount), for young population, a consumption of 375g/w would be sufficient to eliminate the burden while for 25-44 years-old females, 455g/w would reduce IDA, but not entirely. This study highlighted the importance of assessing health risk-benefit per sub-populations and the necessity of communicating the results accordingly.

摘要

食用红肉与结直肠癌(CRC)、心血管疾病(CVD)、食源性病原体相关疾病的风险有关,同时也可能降低缺铁性贫血(IDA)的风险。基于概率模型,将法国人群目前的风险和获益综合为一个单一指标,即伤残调整生命年(DALY)。在法国,每 10 万人中,目前的红肉消费导致 CRC 平均造成 19 个 DALY,CVD 造成 21 个 DALY,食源性病原体导致 7 个 DALY。目前通过饮食摄入铁会导致 IDA 平均造成 15 个 DALY。为了降低风险,针对不同年龄和性别的亚人群制定了不同的情景。在成年和老年人群中,大量食用红肉的人如果遵循目前的建议(少于 500g/周)将受益:CRC 和 CVD 的风险将降低。关于 IDA(用固定的碎牛肉量构建的情景),对于年轻人,375g/周的摄入量足以消除负担,而对于 25-44 岁的女性,455g/周的摄入量可以降低 IDA,但不能完全消除。本研究强调了按亚人群评估健康风险-获益的重要性,并需要相应地传达研究结果。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验