Graduate Program in Health Sciences-Federal University of Grande Dourados (UFGD), Dourados 79804-970, Brazil.
Faculty of Health Sciences-Federal University of Grande Dourados/Universitary Hospital of Federal University of Grande Dourados, Dourados 79823-501, Brazil.
Nutrients. 2019 Sep 2;11(9):2047. doi: 10.3390/nu11092047.
Whey protein (WP) is a dairy food supplement and, due to its effects on fat-free mass (FFM) gain and fat mass (FM) loss, it has been widely consumed by resistance training practitioners. This review analyzed the impact of WP supplementation in its concentrated (WPC), hydrolyzed (WPH) and isolated (WPI) forms, comparing it exclusively to isocaloric placebos. Random effect meta-analyses were performed from the final and initial body composition values of 246 healthy athletes undergoing 64.5 ± 15.3 days of training in eight randomized clinical trials (RCT) collected systematically from five scientific databases. The weighted mean difference (WMD) was statistically significant for FM loss (WMD = -0.96, 95% CI = -1.37, -0.55, < 0.001) and, in the analysis of subgroups, this effect was maintained for the WPC (WMD = -0.63, 95% CI = -1.19, -0.06, = 0.030), with protein content between 51% and 80% (WMD = -1.53; 95% CI = -2.13, -0.93, < 0.001), and only for regular physical activity practitioners (WMD = -0.95; 95% CI = -1.70, -0.19, = 0.014). There was no significant effect on FFM in any of the scenarios investigated ( > 0.05). Due to several and important limitations, more detailed analyses are required regarding FFM gain.
乳清蛋白（WP）是一种乳制品补充剂，由于其对去脂体重（FFM）增加和脂肪体重（FM）减少的影响，它已被广泛用于抗阻训练者。本综述分析了 WP 补充剂的浓缩（WPC）、水解（WPH）和分离（WPI）形式的影响，将其与等热量安慰剂进行了比较。从系统收集的五个科学数据库中的八项随机临床试验（RCT）中 246 名健康运动员的最终和初始体成分值中进行了随机效应荟萃分析。FM 损失的加权均数差（WMD）具有统计学意义（WMD = -0.96，95%置信区间（CI）=-1.37，-0.55， < 0.001），在亚组分析中，WPC 的这种效果仍然存在（WMD = -0.63，95%CI = -1.19，-0.06， = 0.030），其蛋白质含量在 51%至 80%之间（WMD = -1.53；95%CI = -2.13，-0.93， < 0.001），并且仅适用于有规律的体力活动者（WMD = -0.95；95%CI = -1.70，-0.19， = 0.014）。在任何研究情景下，FFM 都没有显著影响（ > 0.05）。由于存在几个重要的局限性，需要对 FFM 增加进行更详细的分析。
