Simpson Joshua D, Smith Samuel A, Thurecht Kristofer J, Such Georgina
Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, the University of Queensland, St Lucia, QLD, 4072, Australia.
School of Chemistry, University of Melbourne, Parkville, VIC, 3010, Australia.
Polymers (Basel). 2019 Sep 2;11(9):1441. doi: 10.3390/polym11091441.
Nanomedicine has generated significant interest as an alternative to conventional cancertherapy due to the ability for nanoparticles to tune cargo release. However, while nanoparticletechnology has promised significant benefit, there are still limited examples of nanoparticles inclinical practice. The low translational success of nanoparticle research is due to the series ofbiological roadblocks that nanoparticles must migrate to be effective, including blood and plasmainteractions, clearance, extravasation, and tumor penetration, through to cellular targeting,internalization, and endosomal escape. It is important to consider these roadblocks holistically inorder to design more effective delivery systems. This perspective will discuss how nanoparticlescan be designed to migrate each of these biological challenges and thus improve nanoparticledelivery systems in the future. In this review, we have limited the literature discussed to studiesinvestigating the impact of polymer nanoparticle structure or composition on therapeutic deliveryand associated advancements. The focus of this review is to highlight the impact of nanoparticlecharacteristics on the interaction with different biological barriers. More specific studies/reviewshave been referenced where possible.
由于纳米颗粒能够调节药物释放，纳米医学作为传统癌症治疗的替代方法已引起了广泛关注。然而，尽管纳米颗粒技术有望带来显著益处，但在临床实践中纳米颗粒的应用实例仍然有限。纳米颗粒研究在转化应用方面成功率较低，这是因为纳米颗粒要发挥作用必须克服一系列生物学障碍，包括与血液和血浆的相互作用、清除、渗出、肿瘤渗透，以及细胞靶向、内化和内体逃逸等。为了设计出更有效的递送系统，全面考虑这些障碍非常重要。本文将探讨如何设计纳米颗粒以克服这些生物学挑战，从而在未来改进纳米颗粒递送系统。在本综述中，我们将所讨论的文献限定为研究聚合物纳米颗粒结构或组成对治疗递送的影响及相关进展的研究。本综述的重点是突出纳米颗粒特性对与不同生物屏障相互作用的影响。在可能的情况下，已引用了更具体的研究/综述。
