Tassi G C, Valcurone G
Boll Ist Sieroter Milan. 1978 Nov 30;57(5):557-74.
The authors outline the immunological and immunogenetic bases of atopy, as well as the radioimmunological techniques employed in the allergological diagnosis and purification as well as standardization of the allergens. The latest trends of the allergological immunotherapy are examined, covering fundamentally two wide fields: the possibility to elicit an aspecific immunological tolerance (soluble suppressor substances of IgE response; Asp-Ser-Asp-Pro-arg pentapeptide, D-GL copolimer conjugated aptens) or the specific induction of "suppressor" mechanisms (allergoids, modified allergens). The preliminary results obtained on sera of patients with a symptomatology highly indicative of penicillin allergy, employing RAST Penicilloil G and Penicilloil V, are also reported.
作者概述了特应性的免疫学和免疫遗传学基础，以及用于变应性疾病诊断、过敏原纯化和标准化的放射免疫技术。文中研究了变应性疾病免疫疗法的最新趋势，主要涵盖两个广泛领域：诱导非特异性免疫耐受的可能性（IgE反应的可溶性抑制物质；天冬氨酸-丝氨酸-天冬氨酸-脯氨酸-精氨酸五肽、D-葡聚糖共聚物结合半抗原）或特异性诱导“抑制”机制（变应原类制剂、修饰的过敏原）。还报告了使用青霉素G和青霉素V放射变应原吸附试验对症状高度提示青霉素过敏患者血清进行检测所获得的初步结果。
