Yang Haiyan, Liu Deliang, Zeng Lin, Peng Siping, Liu Huiling
Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People's Republic of China.
Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Mar 29;16:893-900. doi: 10.2147/DMSO.S401903. eCollection 2023.
Inpatients undergoing colonoscopy may be at increased risk of hypoglycemia. However, few high-quality studies have examined the relationship between hypoglycemia and colonoscopy in patients with type 2 diabetes mellitus (T2DM).
A total of 1016 patients from a large tertiary hospital were enrolled in this retrospective study. We collected demographic information, laboratory indices, colonoscopy information and hypoglycemia information from the enrolled patients during hospitalization. Logistic regression analysis was adopted to estimate the adjusted odds ratios to determine the association between hypoglycemia and colonoscopy.
Hypoglycemia occurred in 80 of 788 (10.1%) patients without colonoscopy exposure and 37 of 228 (16.2%) patients with colonoscopy exposure. 25 patients (67.6%) had hypoglycemic events from 3 hours to 68 hours after the end of colonoscopy. Adjusting for demographic and clinical covariates, the risk of hypoglycemia was 1.99 times higher in those who underwent colonoscopy than in those who did not (OR 1.99, 95% CI 1.25-3.19). The association was consistent in subgroups of females, the elderly, the overweight patients, patients with long duration of disease or patients with suboptimal glycemic control.
A strong association between colonoscopy and an increased risk of hypoglycemia is observed in patients with T2DM. When performing a colonoscopy for diabetics, the risk of hypoglycemia should be considered even within 68 hours after colonoscopy.
接受结肠镜检查的住院患者可能有更高的低血糖风险。然而，很少有高质量研究探讨2型糖尿病（T2DM）患者低血糖与结肠镜检查之间的关系。
本回顾性研究纳入了一家大型三级医院的1016例患者。我们收集了入选患者住院期间的人口统计学信息、实验室指标、结肠镜检查信息和低血糖信息。采用逻辑回归分析来估计调整后的比值比，以确定低血糖与结肠镜检查之间的关联。
788例未接受结肠镜检查的患者中有80例（10.1%）发生低血糖，228例接受结肠镜检查的患者中有37例（16.2%）发生低血糖。25例患者（67.6%）在结肠镜检查结束后3小时至68小时发生低血糖事件。在调整人口统计学和临床协变量后，接受结肠镜检查的患者发生低血糖的风险比未接受者高1.99倍（比值比1.99，95%置信区间1.25 - 3.19）。在女性、老年人、超重患者、病程长的患者或血糖控制不佳的患者亚组中，这种关联是一致的。
在T2DM患者中观察到结肠镜检查与低血糖风险增加之间存在密切关联。对糖尿病患者进行结肠镜检查时，即使在结肠镜检查后68小时内也应考虑低血糖风险。
