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富血小板血浆修复耻骨尿道韧带治疗压力性尿失禁的动物实验研究

An animal experimental study on pubourethral ligament restoration with platelet rich plasma for the treatment of stress urinary incontinence.

作者信息

Nikolopoulos Kostis I, Chrysanthopoulou Eleftheria, Pergialiotis Vasilios, Korrou Laskarina Maria, Perrea Despina N, Dimitroulis Dimitrios, Doumouchtsis Stergios K

机构信息

Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, University of Athens, Greece.

Epsom and St Helier University Hospitals NHS Trust, Urogynaecology, Obstetrics and Gynaecology, London, United Kingdom.

出版信息

Cent European J Urol. 2019;72(2):134-141. doi: 10.5173/ceju.2019.1896. Epub 2019 Jun 4.

DOI:10.5173/ceju.2019.1896
PMID:31482019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6715089/
Abstract

INTRODUCTION

Minimally invasive methods for injured ligament and tendon restoration have been developed and gained popularity in recent years. Injury and relaxation of the pubourethral ligament (PUL) can lead to stress urinary incontinence (SUI). The aim of this study was to investigate the impact of injecting platelet rich plasma (PRP) into the PUL following its surgical transection resulting in SUI, confirmed by leak point pressure (LPP) measurements pre- and post-intervention in an experimental animal model.

MATERIAL AND METHODS

Twenty female adult Sprague-Dawley rats were assigned in 2 groups: 1) treatment group with transection of the PUL and application of PRP at the time of transection and at one month follow-up and 2) a control group, with transection of the PUL only. Leak point pressures (LPPs) were measured prior to transection, immediately following the transection and at 1 and 2 months in both groups.

RESULTS

The median LPPs for the control group were: LPP - preT: 35.6 (29.8-44.8) cmHO, LPP - postT: 14.6 (5.8-19.0) cmHO, LPP - 1 month: 27.3 (19.2-33.8) cmHO, LPP - 2 months: 29.0 (27.0-34.0) cmHO, whereas for the PRP group were: LPP-preT: 40.5 (33.2-46.3) cmHO, LPP - postT: 15.7 (3.0-24.0) cmHO, LPP - 1month: 31.6 (24.8-37.4) cmHO, LPP - 2 months: 36.8 (32.5-45.4) cmHO. PRP injections on transected PULs significantly increased LPPs at one month follow-up [31.6 cmHO vs. 27.3 cmHO, p = .043]. This effect was confirmed at two months [36.8 cmHO vs. 29.0 cmHO, p <.001].

CONCLUSIONS

Injection of PRP into transected PULs significantly improved LPPs at one and two months' follow-up. However, further experimental and clinical research is needed to evaluate the safety and efficacy of this treatment, in clinical practice.

摘要

引言

近年来，用于修复受损韧带和肌腱的微创方法已得到开发并日益普及。耻骨尿道韧带（PUL）的损伤和松弛可导致压力性尿失禁（SUI）。本研究的目的是在实验动物模型中，通过干预前后漏点压力（LPP）测量来证实，研究在因手术切断PUL导致SUI后，向PUL注射富血小板血浆（PRP）的影响。

材料与方法

将20只成年雌性Sprague-Dawley大鼠分为2组：1）治疗组，切断PUL，并在切断时及随访1个月时应用PRP；2）对照组，仅切断PUL。在两组中，于切断前、切断后即刻、1个月和2个月时测量漏点压力（LPP）。

结果

对照组的LPP中位数分别为：切断前LPP：35.6（29.8 - 44.8）cmH₂O，切断后LPP：14.6（5.8 - 19.0）cmH₂O，1个月时LPP：27.3（19.2 - 33.8）cmH₂O，2个月时LPP：29.0（27.0 - 34.0）cmH₂O；而PRP组的LPP中位数分别为：切断前LPP：40.5（33.2 - 46.3）cmH₂O，切断后LPP：15.7（3.0 -

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c620/6715089/d539393469bc/CEJU-72-1896-g008.jpg
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