Pitsillidi Anna, Vona Laura, Bettocchi Stefano, Schiermeier Sven, Noé Günter Karl
Department of OB/GYN, Rheinland Klinikum Dormagen, Dr.-Geldmacher-Straße 20, 41540 Dormagen, Germany.
Department of OB/GYN, University of Witten Herdecke, Alfred-Herrhausen-Straße 50, 58455 Witten, Germany.
J Pers Med. 2025 May 22;15(6):214. doi: 10.3390/jpm15060214.
Pelvic organ prolapse (POP) and stress incontinence (SUI) are very common medical conditions, affecting women's quality of life worldwide. Current surgical and conservative therapies often yield variable outcomes and carry risks of complications or recurrence. Platelet-rich plasma (PRP) has emerged as a promising regenerative approach in various medical disciplines. Its application in urogynecology remains relatively new and emerging. The objective of this study was to review and consolidate existing evidence regarding the application of PRP injections for treating POP and/or SUI. This scoping review was conducted in accordance with the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR). The search strategy included MEDLINE (PubMed), Web of Science, and Scopus databases, covering articles published up to February 2025, with no restrictions on publication date. We included in our review a total of 13 manuscripts and 320 patients at the end of the screening process. A total of ten SUI studies, comprising 273 patients, and three POP studies, involving 47 patients, satisfied all the review criteria. Both clinical entities reported high subjective improvement following PRP treatment. Moreover, PRP appeared to have no significant adverse effects. Our scoping review suggests that PRP may have potential benefits in the treatment of POP and SUI. Nevertheless, the current evidence on its application in this area remains limited. Therefore, well-designed, large-scale randomized controlled trials (RCTs) with extended follow-up periods are urgently needed, in the era of personalized medicine.
盆腔器官脱垂（POP）和压力性尿失禁（SUI）是非常常见的病症，影响着全球女性的生活质量。目前的手术和保守治疗往往效果各异，且存在并发症或复发风险。富血小板血浆（PRP）已成为各医学领域一种有前景的再生治疗方法。其在女性盆底医学中的应用仍相对较新且尚在发展中。本研究的目的是回顾和整合关于PRP注射治疗POP和/或SUI的现有证据。本范围综述按照范围综述的首选报告项目（PRISMA-ScR）进行。检索策略包括MEDLINE（PubMed）、科学网和Scopus数据库，涵盖截至2025年2月发表的文章，对发表日期无限制。在筛选过程结束时，我们的综述共纳入了13篇手稿和320名患者。共有十项关于SUI的研究（涉及273名患者）和三项关于POP的研究（涉及47名患者）符合所有综述标准。两种病症在PRP治疗后均报告了较高的主观改善。此外，PRP似乎没有明显的不良反应。我们的范围综述表明，PRP在治疗POP和SUI方面可能有潜在益处。然而，目前关于其在该领域应用的证据仍然有限。因此，在个性化医疗时代，迫切需要设计良好、大规模且随访期延长的随机对照试验（RCT）。
