Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Dermatol Ther. 2019 Nov;32(6):e13079. doi: 10.1111/dth.13079. Epub 2019 Sep 16.
As one of the most obvious signs of aging, wrinkles have long been the concern of many people and continue to be a major topic in dermal-cosmetic industry. Accordingly, there is a need to develop products with good efficacy and safety profile. The Zanthoxylum bungeanum maxim (ZBM) extract is a natural food which may possess the property of a toxin-like botulinum. To evaluate the efficacy and safety of a formulation that contains 2% ZBM pericarp extract in the treatment of wrinkles. Twenty females aged 35-60 years old were enrolled in this randomized, vehicle-controlled, double-blind, and split-face trial. The trial lasted for 30 days, when participants randomly used formulations containing 2% ZBM extract on one side of the temporal canthus and vehicle formulation on the other side. Skin roughness, skin hydration, and skin elasticity were evaluated by Primospico, Corneometer® CM825, and Cutometer® MPA580, respectively. The formulation containing 2% ZBM extract has a significant short-term anti-crow's feet effect compared with vehicle. No adverse effect was shown during the study. Topical application of 2% ZBM extract is tolerable and can be used as an effective cosmetic agent for short-term wrinkle treatment.
作为衰老最明显的迹象之一，皱纹一直是许多人的关注焦点，并且仍然是皮肤化妆品行业的主要话题。因此，需要开发具有良好疗效和安全性的产品。花椒提取物（ZBM）是一种天然食品，可能具有类毒素肉毒杆菌的特性。评估含有 2%ZBM 果皮提取物的制剂治疗皱纹的疗效和安全性。本随机、赋形剂对照、双盲、分面试验纳入了 20 名年龄在 35-60 岁的女性。试验持续 30 天，参与者随机在颞部一侧使用含有 2%ZBM 提取物的制剂，另一侧使用赋形剂。使用 Primospico、Corneometer® CM825 和 Cutometer® MPA580 分别评估皮肤粗糙度、皮肤水分和皮肤弹性。与赋形剂相比，含有 2%ZBM 提取物的制剂具有显著的短期抗鱼尾纹效果。研究过程中未显示任何不良反应。局部应用 2%ZBM 提取物是可以耐受的，可以作为短期皱纹治疗的有效化妆品制剂。
