Wang Tianyou, Guo Linghong, Wu Shuwei, Xu Yuanyuan, Song Junmei, Yang Yi, Zhang Hengjie, Li Dongcui, Li Yiwen, Jiang Xian, Gu Zhipeng
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Adv Sci (Weinh). 2024 Apr;11(16):e2310012. doi: 10.1002/advs.202310012. Epub 2024 Feb 15.
Natural evolution has nurtured a series of active molecules that play vital roles in physiological systems, but their further applications have been severely limited by rapid deactivation, short cycle time, and potential toxicity after isolation. For instance, the instability of structures and properties has greatly descended when sanshool is derived from Zanthoxylum xanthoxylum. Herein, natural polyphenols are employed to boost the key properties of sanshool by fabricating a series of nanoparticles (NPs). The intracellular evaluation and in vivo animal model are conducted to demonstrate the decreased photodamage score and skin-fold thickness of prepared NPs, which can be attributed to the better biocompatibility, improved free radical scavenging, down-regulated apoptosis ratios, and reduced DNA double-strand breaks compared to naked sanshool. This work proposes a novel strategy to boost the key properties of naturally occurring active molecules with the assistance of natural polyphenol-based platforms.
自然进化孕育了一系列在生理系统中发挥重要作用的活性分子，但它们的进一步应用受到快速失活、短循环时间以及分离后潜在毒性的严重限制。例如，当山嵛菜碱从花椒中提取出来时，其结构和性质的不稳定性大大降低。在此，通过制备一系列纳米颗粒（NPs），利用天然多酚来增强山嵛菜碱的关键特性。进行了细胞内评估和体内动物模型实验，以证明所制备的纳米颗粒的光损伤评分和皮肤褶皱厚度降低，这可归因于与裸山嵛菜碱相比更好的生物相容性、改善的自由基清除能力、下调的凋亡率以及减少的DNA双链断裂。这项工作提出了一种在基于天然多酚的平台辅助下增强天然活性分子关键特性的新策略。
