Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Laboratory Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arch Physiol Biochem. 2022 Feb;128(1):24-31. doi: 10.1080/13813455.2019.1661496. Epub 2019 Sep 4.
We aimed to study the correlation of adiponectin level with insulin resistance (IR), carotid intima-media thickness (cIMT), and various obesity indices especially visceral adipose tissue (VAT) thickness, and visceral adiposity index (VAI), in patients with NAFLD ( = 41), T2D ( = 22), NAFLD + T2D ( = 41), and healthy subjects ( = 20). Results showed the median level of adiponectin in patients with NAFLD (2.97 μg/mL) and ones with NAFLD + T2D (3.21 μg/mL) is significantly lower rather than in controls (4.39 μg/mL). Moreover, VAI is the only predictor for adiponectin concentration in the combination of patient groups and also in all participants independent of IR and other obesity indices. Adiponectin level had also a positive correlation with cIMT and IR in NAFLD patients. Interestingly, lower level of adiponectin was associated with the presence of T2D, NAFLD, and NAFLD + T2D independent of IR and obesity indices. Collectively, it seems that VAI reflecting visceral adipose tissue function is a possible predictor of adiponectin level.
我们旨在研究脂联素水平与胰岛素抵抗（IR）、颈动脉内膜中层厚度（cIMT）以及各种肥胖指数（尤其是内脏脂肪组织[VAT]厚度和内脏脂肪指数[VAI]）在非酒精性脂肪性肝病（NAFLD）患者（ = 41）、2 型糖尿病（T2D）患者（ = 22）、NAFLD + T2D 患者（ = 41）和健康受试者（ = 20）中的相关性。结果显示，NAFLD 患者（2.97μg/mL）和 NAFLD + T2D 患者（3.21μg/mL）的脂联素中位数水平明显低于对照组（4.39μg/mL）。此外，VAI 是患者组和所有参与者中除 IR 和其他肥胖指数外，唯一预测脂联素浓度的因素。脂联素水平与 NAFLD 患者的 cIMT 和 IR 呈正相关。有趣的是，较低的脂联素水平与 T2D、NAFLD 和 NAFLD + T2D 的存在独立于 IR 和肥胖指数相关。总的来说，反映内脏脂肪组织功能的 VAI 似乎是脂联素水平的一个可能预测因素。
