Mosbech H, Osterballe O
Medical Dept., State University Hospital Copenhagen, Denmark.
Allergy. 1988 Oct;43(7):523-9. doi: 10.1111/j.1398-9995.1988.tb01631.x.
In a previous study, 39 adults with grass pollen allergy were hyposensitized for approximately 2 1/2 years. Treatment was performed in a double-blind fashion with extract made from timothy grass--either Alutard SQ 20-component extract or a purified 2-component extract, including only the two major allergens Phl p V and VI. Standardized symptom + medicine scores and challenge tests demonstrated a clinical effect, most markedly in the group receiving 20-component extract. Six years after termination of treatment, 38 patients could be approached and 16 in each group were examined and repeated symptoms scoring during the subsequent season. When adjustment for variations in pollen counts were made, medicine + symptom scores stayed low during the follow-up period. Specific IgE-antibodies against timothy showed an increase to initial values during the same period, whereas total IgE antibodies remained low. Skin prick test reactions with timothy allergen tended to increase but were still smaller than before treatment. Retrospectively, the patients reported symptoms to have stabilized or even further decreased after termination of treatment, with no significant difference between groups. In conclusion, the clinical effect was still present more than 6 years after termination of treatment. Some in vitro parameters tended to return to pretreatment level. The spontaneous course of the disease in non-hyposensitized patients was not investigated.
在之前的一项研究中，39名对草花粉过敏的成年人进行了约两年半的减敏治疗。治疗采用双盲方式，使用梯牧草提取物——Alutard SQ 20组分提取物或纯化的2组分提取物，后者仅包含两种主要过敏原Phl p V和VI。标准化症状+药物评分和激发试验显示出临床效果，在接受20组分提取物的组中最为明显。治疗结束六年后，38名患者能够接受随访，每组16名患者接受检查，并在随后的季节重复症状评分。在对花粉计数变化进行调整后，药物+症状评分在随访期间保持较低水平。针对梯牧草的特异性IgE抗体在同一时期增加至初始值，而总IgE抗体仍保持较低水平。用梯牧草过敏原进行的皮肤点刺试验反应趋于增加，但仍小于治疗前。回顾性来看，患者报告治疗结束后症状已稳定甚至进一步减轻，两组之间无显著差异。总之，治疗结束六年多后临床效果仍然存在。一些体外参数倾向于恢复到治疗前水平。未对未进行减敏治疗患者的疾病自然病程进行研究。
