García García M J, López-Herce Cid J, Martínez Bermejo A, Perdikidi Olivieri L, Rubio de la Iglesia F, Hernández González J
Unidad de Cuidados Intensivos Pediátricos, Hospital Infantil La Paz, Madrid.
An Esp Pediatr. 1988 Oct;29(4):324-6.
A 5 years old girl with status epilepticus refractory to treatment with Diphenylhydantoin at a dose of 30 mg/kg/day and Thiopental in continuous IV perfusion at a dose of 4 mg/kg/h is presented. Control of status was achieved by continuous IV perfusion of Chlormethiazole at a dose of 10 mg/kg/h which also caused respiratory depression. Seizure activity reappeared after IV perfusion of Chlormethiazole was retired, and could be controlled only with Sodium Valproate. Mechanisms of action of Chlormethiazole and its effectiveness in treatment of refractory status epilepticus are revised.
