State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China.
J Mater Chem B. 2019 Sep 18;7(36):5449-5460. doi: 10.1039/c9tb01467e.
Great efforts have been devoted to exploiting silicate bioceramics for various applications in soft tissue regeneration, owing to their excellent bioactivity. Based on the inherent ability of silicate bioceramics to repair tissue, bioactive ions are easily incorporated into silicate bioceramics to endow them with extra biological properties, such as enhanced angiogenesis, antibiosis, enhanced osteogenesis, and antitumor effect, which significantly expands the application of multifunctional silicate bioceramics. Furthermore, silicate nanobioceramics with unique structures have been widely employed for tumor therapy. In recent years, the novel applications of silicate bioceramics for both tissue regeneration and tumor therapy have substantially grown. Eliminating the skin tumors first and then repairing the skin wounds has been widely investigated by our groups, which might shed some light on treating other soft tissue tumor or tumor-induced defects. This review first describes the recent advances made in the development of silicate bioceramics as therapeutic platforms for soft tissue regeneration. We then highlight the major silicate nanobioceramics used for tumor therapy. Silicate bioceramics for both soft tissue regeneration and tumor therapy are further emphasized. Finally, challenges and future directions of silicate bioceramics stepping into the clinics are discussed. This review will inspire researchers to create the efficient and functional silicate bioceramics needed for regeneration and tumor therapy of other tissues.
人们致力于开发硅酸盐生物陶瓷，以将其应用于软组织再生的各个领域，这主要是因为其具有出色的生物活性。基于硅酸盐生物陶瓷修复组织的固有能力，可将生物活性离子轻易地掺入硅酸盐生物陶瓷中，从而赋予其额外的生物学特性，例如增强血管生成、抗菌、增强成骨和抗肿瘤作用，这极大地扩展了多功能硅酸盐生物陶瓷的应用范围。此外，具有独特结构的硅酸盐纳米生物陶瓷已被广泛用于肿瘤治疗。近年来，硅酸盐生物陶瓷在组织再生和肿瘤治疗方面的新应用得到了极大的发展。我们小组广泛研究了先消除皮肤肿瘤，然后再修复皮肤伤口的方法，这可能为治疗其他软组织肿瘤或肿瘤引起的缺损提供一些思路。本综述首先描述了近年来开发用于软组织再生治疗平台的硅酸盐生物陶瓷的最新进展。然后，我们重点介绍了用于肿瘤治疗的主要硅酸盐纳米生物陶瓷。进一步强调了用于软组织再生和肿瘤治疗的硅酸盐生物陶瓷。最后，讨论了硅酸盐生物陶瓷进入临床应用所面临的挑战和未来发展方向。本综述将激发研究人员创造出用于其他组织再生和肿瘤治疗的高效且功能强大的硅酸盐生物陶瓷。
