Wang Xiaocheng, Tang Min
Department of NanoEngineering University of California San Diego San Diego California USA.
Smart Med. 2022 Dec 27;1(1):e20220032. doi: 10.1002/SMMD.20220032. eCollection 2022 Dec.
Regeneration of both anatomic and functional integrity of the skin tissues after injury represents a huge challenge considering the sophisticated healing process and variability of specific wounds. In the past decades, numerous efforts have been made to construct bioceramic-based wound dressing materials with ion-mediated multifunctionality for facilitating the healing process. In this review, the state-of-the-art progress on bioceramic materials with ion-mediated bioactivity for wound healing is summarized. Followed by a brief discussion on the bioceramic materials with ion-mediated biological activities, the emerging bioceramic-based materials are highlighted for wound healing applications owing to their ion-mediated bioactivities, including anti-infection function, angiogenic activity, improved skin appendage regeneration, antitumor effect, and so on. Finally, concluding remarks and future perspectives of bioceramic-based wound dressing materials for clinical practice are briefly discussed.
考虑到复杂的愈合过程和特定伤口的变异性，损伤后皮肤组织的解剖和功能完整性的再生是一项巨大的挑战。在过去几十年中，人们做出了许多努力来构建具有离子介导多功能性的生物陶瓷基伤口敷料材料，以促进愈合过程。在这篇综述中，总结了具有离子介导生物活性的生物陶瓷材料在伤口愈合方面的最新进展。在简要讨论了具有离子介导生物活性的生物陶瓷材料之后，重点介绍了新兴的生物陶瓷基材料在伤口愈合应用中的离子介导生物活性，包括抗感染功能、血管生成活性、改善皮肤附属器再生、抗肿瘤作用等。最后，简要讨论了生物陶瓷基伤口敷料材料在临床实践中的总结和未来展望。
