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加拿大初级保健中慢性肾脏病管理的质量。

Quality of Chronic Kidney Disease Management in Canadian Primary Care.

机构信息

Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

出版信息

JAMA Netw Open. 2019 Sep 4;2(9):e1910704. doi: 10.1001/jamanetworkopen.2019.10704.

Abstract

IMPORTANCE

Although patients with chronic kidney disease (CKD) are routinely managed in primary care settings, no nationally representative study has assessed the quality of care received by these patients in Canada.

OBJECTIVE

To evaluate the current state of CKD management in Canadian primary care practices to identify care gaps to guide development and implementation of national quality improvement initiatives.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study leveraged Canadian Primary Care Sentinel Surveillance Network data from January 1, 2010, to December 31, 2015, to develop a cohort of 46 162 patients with CKD managed in primary care practices. Data analysis was performed from August 8, 2018, to July 31, 2019.

MAIN OUTCOMES AND MEASURES

The study examined the proportion of patients with CKD who met a set of 12 quality indicators in 6 domains: (1) detection and recognition of CKD, (2) testing and monitoring of kidney function, (3) use of recommended medications, (4) monitoring after initiation of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), (5) management of blood pressure, and (6) monitoring for glycemic control in those with diabetes and CKD. The study also analyzed associations of divergence from these quality indicators.

RESULTS

The cohort comprised 46 162 patients (mean [SD] age, 69.2 [14.0] years; 25 855 [56.0%] female) with stage 3 to 5 CKD. Only 4 of 12 quality indicators were met by 75% or more of the study cohort. These indicators were receipt of an outpatient serum creatinine test within 18 months after confirmation of CKD, receipt of blood pressure measurement at any time during follow-up, achieving a target blood pressure of 140/90 mm Hg or lower, and receiving a hemoglobin A1c test for monitoring diabetes during follow-up. Indicators in the domains of detection and recognition of CKD, testing and monitoring of kidney function (specifically, urine albumin to creatinine ratio testing), use of recommended medications, and appropriate monitoring after initiation of treatment with ACEIs or ARBs were not met. Only 6529 patients (18.4%) with CKD received a urine albumin test within 6 months of CKD diagnosis, and 3954 (39.4%) had a second measurement within 6 months of an abnormal baseline urine albumin level. Older age (≥85 years) and CKD stage 5 were significantly associated with not satisfying the criteria for the quality indicators across all domains. Across age categories, younger patients (aged 18-49 years) and older patients (≥75 years) were less likely to be tested for albuminuria (314 of 1689 patients aged 18-49 years [18.5%], 1983 of 11 919 patients aged 75-84 years [61.6%], and 614 of 5237 patients aged ≥85 years [11.7%] received the urine albumin to creatinine ratio test within 6 months of initial estimated glomerular filtration rate <60 mL/min per 1.73 m2; P < .001). Patients aged 18 to 49 years were less commonly prescribed recommended medications (222 of 2881 [7.7%]), whereas patients aged 75 to 84 years were prescribed ACEIs or ARBs most frequently (2328 of 5262 [44.2%]; P < .001).

CONCLUSIONS AND RELEVANCE

The findings suggest that management of CKD across primary care practices in Canada varies according to quality indicator. This study revealed potential priority areas for quality improvement initiatives in Canadian primary care practices.

摘要

重要性

尽管慢性肾脏病 (CKD) 患者通常在初级保健环境中接受管理,但没有全国代表性研究评估过这些患者在加拿大接受的护理质量。

目的

评估加拿大初级保健实践中 CKD 管理的现状,以确定护理差距,从而指导国家质量改进计划的制定和实施。

设计、设置和参与者:本横断面研究利用加拿大初级保健监测网络数据,从 2010 年 1 月 1 日至 2015 年 12 月 31 日,确定了一组在初级保健实践中接受管理的 46162 名 CKD 患者。数据分析于 2018 年 8 月 8 日至 2019 年 7 月 31 日进行。

主要结果和措施

研究检查了符合 6 个领域 12 个质量指标的 CKD 患者比例:(1)CKD 的检测和识别,(2)肾功能的检测和监测,(3)推荐药物的使用,(4)血管紧张素转换酶抑制剂(ACEI)或血管紧张素 II 受体阻滞剂(ARB)启动后的监测,(5)血压管理,以及(6)伴有糖尿病和 CKD 患者的血糖控制监测。该研究还分析了与这些质量指标偏离的关联。

结果

队列包括 46162 名患者(平均[SD]年龄,69.2[14.0]岁;25855[56.0%]为女性),患有 3 至 5 期 CKD。只有 12 个质量指标中的 4 个被研究队列的 75%或更多患者满足。这些指标是在确诊 CKD 后 18 个月内接受门诊血肌酐检测、在随访期间任何时候接受血压测量、达到 140/90mmHg 或更低的目标血压、以及在随访期间接受血红蛋白 A1c 测试以监测糖尿病。在 CKD 的检测和识别、肾功能检测和监测(具体为尿白蛋白与肌酐比值检测)、推荐药物的使用以及 ACEI 或 ARB 治疗启动后的适当监测等领域的指标没有得到满足。只有 6529 名(18.4%)CKD 患者在 CKD 确诊后 6 个月内接受了尿白蛋白检测,3954 名(39.4%)患者在异常基线尿白蛋白水平后 6 个月内进行了第二次检测。年龄较大(≥85 岁)和 CKD 第 5 期与所有领域不符合质量指标的显著相关。在各年龄组中,年龄较小(18-49 岁)和年龄较大(≥75 岁)的患者进行白蛋白尿检测的可能性较低(18-49 岁的 1689 名患者中有 314 名[18.5%],75-84 岁的 11919 名患者中有 1983 名[61.6%],≥85 岁的 5237 名患者中有 614 名[11.7%]在初始估算肾小球滤过率 <60mL/min/1.73m2 时接受尿白蛋白与肌酐比值检测;P<0.001)。年龄在 18 至 49 岁的患者较少接受推荐药物治疗(2881 名患者中有 222 名[7.7%]),而 75 至 84 岁的患者最常开 ACEI 或 ARB(5262 名患者中有 2328 名[44.2%];P<0.001)。

结论和相关性

研究结果表明,加拿大初级保健实践中 CKD 的管理因质量指标而异。本研究揭示了加拿大初级保健实践中质量改进计划的潜在优先领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8878/6727682/ebc95f877c3f/jamanetwopen-2-e1910704-g001.jpg

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