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2012-2019 年美国按种族和民族划分的慢性肾脏病护理趋势。

Trends in Chronic Kidney Disease Care in the US by Race and Ethnicity, 2012-2019.

机构信息

Division of Nephrology, University of California, San Francisco.

OptumLabs Visiting Fellow, OptumLabs, Eden Prairie, Minnesota.

出版信息

JAMA Netw Open. 2021 Sep 1;4(9):e2127014. doi: 10.1001/jamanetworkopen.2021.27014.

Abstract

IMPORTANCE

Significant racial and ethnic disparities in chronic kidney disease (CKD) progression and outcomes are well documented, as is low use of guideline-recommended CKD care.

OBJECTIVE

To examine guideline-recommended CKD care delivery by race and ethnicity in a large, diverse population.

DESIGN, SETTING, AND PARTICIPANTS: In this serial cross-sectional study, adult patients with CKD that did not require dialysis, defined as a persistent estimated glomerular filtration rate less than 60 mL/min/1.73 m2 or a urine albumin-creatinine ratio of 30 mg/g or higher for at least 90 days, were identified in 2-year cross-sections from January 1, 2012, to December 31, 2019. Data from the OptumLabs Data Warehouse, a national data set of administrative and electronic health record data for commercially insured and Medicare Advantage patients, were used.

EXPOSURES

The independent variables were race and ethnicity, as reported in linked electronic health records.

MAIN OUTCOMES AND MEASURES

On the basis of guideline-recommended CKD care, the study examined care delivery process measures (angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker prescription for albuminuria, statin prescription, albuminuria testing, nephrology care for CKD stage 4 or higher, and avoidance of chronic nonsteroidal anti-inflammatory drug prescription) and care delivery outcome measures (blood pressure and diabetes control).

RESULTS

A total of 452 238 patients met the inclusion criteria (mean [SD] age, 74.0 [10.2] years; 262 089 [58.0%] female; a total of 7573 [1.7%] Asian, 49 970 [11.0%] Black, 15 540 [3.4%] Hispanic, and 379 155 [83.8%] White). Performance on process measures was higher among Asian, Black, and Hispanic patients compared with White patients for angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker use (79.8% for Asian patients, 76.7% for Black patients, and 79.9% for Hispanic patients compared with 72.3% for White patients in 2018-2019), statin use (72.6% for Asian patients, 69.1% for Black patients, and 74.1% for Hispanic patients compared with 61.5% for White patients), nephrology care (64.8% for Asian patients, 72.9% for Black patients, and 69.4% for Hispanic patients compared with 58.3% for White patients), and albuminuria testing (53.9% for Asian patients, 41.0% for Black patients, and 52.6% for Hispanic patients compared with 30.7% for White patients). Achievement of blood pressure control to less than 140/90 mm Hg was similar or lower among Asian (71.8%), Black (63.3%), and Hispanic (69.8%) patients compared with White patients (72.9%). Achievement of diabetes control with hemoglobin A1c less than 7.0% was 50.1% in Asian patients, 49.3% in Black patients, and 46.0% in Hispanic patients compared with 50.3% for White patients.

CONCLUSIONS AND RELEVANCE

Higher performance on CKD care process measures among Asian, Black, and Hispanic patients suggests that differences in medication prescription and diagnostic testing are unlikely to fully explain known disparities in CKD progression and kidney failure. Improving care delivery processes alone may be inadequate for reducing these disparities.

摘要

重要性

慢性肾脏病(CKD)进展和结局的显著种族和民族差异以及指南推荐的 CKD 护理的低使用率已有充分记录。

目的

在一个大型、多样化的人群中,检查按种族和族裔推荐的 CKD 护理的实施情况。

设计、设置和参与者:在这项连续的横断面研究中,在 2012 年 1 月 1 日至 2019 年 12 月 31 日期间,从每两年的横断面中确定了不需要透析的 CKD 患者,定义为持续估计肾小球滤过率低于 60 mL/min/1.73 m2 或尿液白蛋白/肌酐比值大于或等于 30 mg/g 至少 90 天。使用了来自 OptumLabs Data Warehouse 的数据,这是一个包含商业保险和 Medicare Advantage 患者行政和电子健康记录数据的国家数据集。

暴露因素

独立变量是种族和族裔,在链接的电子健康记录中报告。

主要结果和措施

根据指南推荐的 CKD 护理,该研究检查了护理提供过程指标(白蛋白尿时使用血管紧张素转换酶抑制剂或血管紧张素 II 受体阻滞剂、他汀类药物处方、白蛋白尿检测、CKD 4 期或更高阶段的肾病护理以及避免使用慢性非甾体抗炎药处方)和护理提供结果指标(血压和糖尿病控制)。

结果

共有 452238 名患者符合纳入标准(平均[标准差]年龄为 74.0[10.2]岁;女性 262089 人[58.0%];7573 人[1.7%]为亚洲人,49970 人[11.0%]为黑人,15540 人[3.4%]为西班牙裔,379155 人[83.8%]为白人)。与白人患者相比,亚洲、黑人和西班牙裔患者在使用血管紧张素转换酶抑制剂和血管紧张素 II 受体阻滞剂(2018-2019 年亚洲患者为 79.8%,黑人患者为 76.7%,西班牙裔患者为 79.9%,而白人患者为 72.3%)、他汀类药物使用(亚洲患者为 72.6%,黑人患者为 69.1%,西班牙裔患者为 74.1%,而白人患者为 61.5%)、肾病护理(亚洲患者为 64.8%,黑人患者为 72.9%,西班牙裔患者为 69.4%,而白人患者为 58.3%)和白蛋白尿检测(亚洲患者为 53.9%,黑人患者为 41.0%,西班牙裔患者为 52.6%,而白人患者为 30.7%)方面的表现更高。将血压控制在低于 140/90 mm Hg 的比例在亚洲人(71.8%)、黑人(63.3%)和西班牙裔(69.8%)患者中与白人患者(72.9%)相似或较低。将血红蛋白 A1c 控制在低于 7.0%的糖尿病控制率在亚洲患者中为 50.1%,黑人患者中为 49.3%,西班牙裔患者中为 46.0%,而白人患者中为 50.3%。

结论和相关性

亚洲、黑人和西班牙裔患者在 CKD 护理过程指标上的更高表现表明,药物处方和诊断检测方面的差异不太可能完全解释 CKD 进展和肾衰竭方面的已知差异。仅改善护理提供过程可能不足以减少这些差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dccf/8477264/87bfa6eac48b/jamanetwopen-e2127014-g001.jpg

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