Martinetti M, Tafi A, Dugoujon J M, Mazzacane D, Blanc M, Cuccia Belvedere M
Laboratorio HLA, Centro Trasfusionale A.V.I.S., Pavia, Italy.
Dis Markers. 1988 Oct-Dec;6(4):257-62.
We detected and analysed the Gm and Km allotype markers of Ig in 57 patients affected by uveitis, an ocular inflammation with multifactorial etiology. The aim of the present study has been to investigate the possibility that different immunogenetic factors predispose to the various forms of the disease. We found a statistically significant alteration of Km(1) allele frequency (relative risk = 2.65). That seems to predispose to anterior uveitis, especially when associated with a blank at HLA-A locus (RR = 7.83) but predispose to the posterior form when in combination with HLA-B38 (RR = 19.24). Moreover, a high frequency of Km(1)/A blank phenotypic association was noticed in uveitis with infectious aetiology (RR rising to 10.44). The Km(1) genotype may itself predispose to uveitis and its combination with different HLA alleles could enhance the susceptibility to one particular form rather than to another.
我们检测并分析了57例葡萄膜炎患者免疫球蛋白的Gm和Km同种异型标记，葡萄膜炎是一种病因多因素的眼部炎症。本研究的目的是调查不同免疫遗传因素导致该疾病各种形式的可能性。我们发现Km(1)等位基因频率有统计学意义的改变（相对风险=2.65）。这似乎易患前葡萄膜炎，尤其是与HLA - A位点空白相关时（相对风险=7.83），但与HLA - B38组合时易患后葡萄膜炎（相对风险=19.24）。此外，在感染性病因的葡萄膜炎中发现Km(1)/A空白表型关联的频率很高（相对风险升至10.44）。Km(1)基因型本身可能易患葡萄膜炎，其与不同HLA等位基因的组合可能会增加对一种特定形式而非另一种形式的易感性。
