Raděj Jaroslav, Horák Jan, Harazim Martin, Matějovič Martin
Vnitr Lek. 2019 Summer;65(6):416-424.
Supporting clearance of a toxic substance by an extracorporeal removal technique is one of the advanced treatment methods applied in poisoned patient management. General indications stem from toxicokinetics of the poison while individual indications are determined by poisoning severity. The first part of this review deals in detail with particular options of extracorporeal treatment in toxicology and also with its specific application when treating lithium and salicylates poisoning or dabigatran overdose. The aim of this review is to facilitate the clinicians and nephrologists decision making whether to indicate this invasive procedure, to communicate and summarize the existing recommendations and to highlight the most important ways of how to treat poisoning by specific toxic substances.
通过体外清除技术辅助清除有毒物质是中毒患者管理中应用的先进治疗方法之一。一般适应症源于毒物的毒代动力学，而个体适应症则由中毒严重程度决定。本综述的第一部分详细讨论了毒理学中体外治疗的具体选择，以及治疗锂和水杨酸盐中毒或达比加群过量时的具体应用。本综述的目的是帮助临床医生和肾病学家决定是否采用这种侵入性程序，交流和总结现有建议，并强调治疗特定有毒物质中毒的最重要方法。
