Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA; College of Pharmacy, University of Rhode Island, Kingston, RI, USA.
Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA; College of Pharmacy, University of Rhode Island, Kingston, RI, USA; Center of Innovation in Long-Term Support Services, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Diagn Microbiol Infect Dis. 2019 Dec;95(4):114877. doi: 10.1016/j.diagmicrobio.2019.114877. Epub 2019 Jul 31.
Biofilm formation of multidrug and extensively drug resistant Klebsiella pneumoniae isolates is poorly understood. We investigated 139 diverse clinical K. pneumoniae isolates that possess various resistance patterns to evaluate the relationship between biofilm formation and resistance. Antimicrobial resistance was compared among a diverse collection of weak versus strong biofilm-forming K. pneumoniae, and predictors of strong biofilm formation were identified. Multi-drug resistant isolates were more common among weak (97.9%) versus strong biofilm formers (76%; P = 0.002). Carbapenem-resistant K. pneumoniae were 91% less likely to form strong biofilm (odds ratio 0.09; 95% confidence interval 0.02-0.33). The statistically significant inverse relationship between biofilm formation and antibiotic resistance suggests that virulence may be a trade-off for survival.
多药和广泛耐药肺炎克雷伯菌分离株的生物膜形成机制了解甚少。我们研究了 139 种不同的临床肺炎克雷伯菌分离株，这些分离株具有不同的耐药模式，以评估生物膜形成与耐药性之间的关系。比较了不同强弱生物膜形成肺炎克雷伯菌之间的抗菌药物耐药性，并确定了强生物膜形成的预测因子。弱生物膜形成者（97.9%）比强生物膜形成者（76%）中多药耐药分离株更为常见（P=0.002）。碳青霉烯类耐药肺炎克雷伯菌形成强生物膜的可能性降低 91%（比值比 0.09；95%置信区间 0.02-0.33）。生物膜形成与抗生素耐药性之间呈显著负相关，这表明毒力可能是生存的一种权衡。
