Li Lifeng, Gao Xueyan, Li Mingchao, Liu Yuchun, Ma Jiayue, Wang Xiaolei, Yu Zhidan, Cheng Weyland, Zhang Wancun, Sun Huiqing, Song Xiaorui, Wang Zhaobao
Henan International Joint Laboratory of Children's Infectious Diseases, Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Front Cell Infect Microbiol. 2024 Feb 23;14:1324895. doi: 10.3389/fcimb.2024.1324895. eCollection 2024.
is a Gram-negative bacterium within the family that can cause multiple systemic infections, such as respiratory, blood, liver abscesses and urinary systems. Antibiotic resistance is a global health threat and warrants special attention due to its resistance to most modern day antibiotics. Biofilm formation is a critical obstruction that enhances the antibiotic resistance of . However, knowledge on the molecular mechanisms of biofilm formation and its relation with antibiotic resistance in is limited. Understanding the molecular mechanisms of biofilm formation and its correlation with antibiotic resistance is crucial for providing insight for the design of new drugs to control and treat biofilm-related infections. In this review, we summarize recent advances in genes contributing to the biofilm formation of , new progress on the relationship between biofilm formation and antibiotic resistance, and new therapeutic strategies targeting biofilms. Finally, we discuss future research directions that target biofilm formation and antibiotic resistance of this priority pathogen.
是该菌科中的一种革兰氏阴性菌，可引起多种全身感染，如呼吸道、血液、肝脓肿和泌尿系统感染。抗生素耐药性是一种全球健康威胁，因其对大多数现代抗生素具有耐药性而值得特别关注。生物膜形成是增强其抗生素耐药性的关键障碍。然而，关于生物膜形成的分子机制及其与抗生素耐药性的关系的知识在中是有限的。了解生物膜形成的分子机制及其与抗生素耐药性的相关性对于为控制和治疗生物膜相关感染的新药设计提供见解至关重要。在本综述中，我们总结了有助于生物膜形成的基因的最新进展、生物膜形成与抗生素耐药性之间关系的新进展以及针对生物膜的新治疗策略。最后，我们讨论了针对这种重点病原体的生物膜形成和抗生素耐药性的未来研究方向。
