曲马多与华法林联用导致出血和国际标准化比值升高
Bleeding and Elevated INR Secondary to Concomitant Tramadol and Warfarin Administration.
作者信息
Veltri Keith T, Olsufka William A
出版信息
P T. 2019 Sep;44(9):546-548.
Abstract
The exact mechanism of a tramadol-warfarin interaction has not been fully determined. The authors present a case study that illustrates the risks.
摘要
曲马多与华法林相互作用的确切机制尚未完全明确。作者呈现了一个案例研究来说明其中的风险。
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本文引用的文献
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[Pharmaceutical care of serious bleeding induced by tramadol-warfarin interaction: a case report].
Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Oct 18;46(5):809-13.
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PharmGKB summary: tramadol pathway.PharmGKB总结：曲马多作用途径。
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Concurrent use of tramadol and oral vitamin K antagonists and the risk of excessive anticoagulation: a register-based nested case-control study.曲马多与口服维生素 K 拮抗剂同时使用与抗凝过度风险：基于登记的巢式病例对照研究。
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Administration of tramadol or ibuprofen increases the INR level in patients on warfarin.服用曲马多或布洛芬会增加服用华法林患者的国际标准化比值（INR）水平。
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