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曲马多与华法林联用导致出血和国际标准化比值升高

Bleeding and Elevated INR Secondary to Concomitant Tramadol and Warfarin Administration.

作者信息

Veltri Keith T, Olsufka William A

出版信息

P T. 2019 Sep;44(9):546-548.

PMID:31485149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6705477/
Abstract

The exact mechanism of a tramadol-warfarin interaction has not been fully determined. The authors present a case study that illustrates the risks.

摘要

曲马多与华法林相互作用的确切机制尚未完全明确。作者呈现了一个案例研究来说明其中的风险。

相似文献

1
Bleeding and Elevated INR Secondary to Concomitant Tramadol and Warfarin Administration.曲马多与华法林联用导致出血和国际标准化比值升高
P T. 2019 Sep;44(9):546-548.
2
Successful anticoagulation and continuation of tramadol therapy in the setting of a tramadol-warfarin interaction.在曲马多与华法林相互作用的情况下成功进行抗凝及继续曲马多治疗。
Pharmacotherapy. 2006 Nov;26(11):1654-7. doi: 10.1592/phco.26.11.1654.
3
[Effects of Tramadol Coadministration on Prothrombin Time-International Normalized Ratio in Patients Receiving Warfarin].[曲马多联合用药对华法林治疗患者凝血酶原时间-国际标准化比值的影响]
Yakugaku Zasshi. 2017;137(8):999-1003. doi: 10.1248/yakushi.16-00270.
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本文引用的文献

1
[Pharmaceutical care of serious bleeding induced by tramadol-warfarin interaction: a case report].
Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Oct 18;46(5):809-13.
2
PharmGKB summary: tramadol pathway.PharmGKB总结：曲马多作用途径。
Pharmacogenet Genomics. 2014 Jul;24(7):374-80. doi: 10.1097/FPC.0000000000000057.
3
Concurrent use of tramadol and oral vitamin K antagonists and the risk of excessive anticoagulation: a register-based nested case-control study.曲马多与口服维生素 K 拮抗剂同时使用与抗凝过度风险：基于登记的巢式病例对照研究。
Eur J Clin Pharmacol. 2013 Mar;69(3):641-6. doi: 10.1007/s00228-012-1363-x. Epub 2012 Jul 31.
4
Administration of tramadol or ibuprofen increases the INR level in patients on warfarin.服用曲马多或布洛芬会增加服用华法林患者的国际标准化比值（INR）水平。
Eur J Clin Pharmacol. 2013 Feb;69(2):291-2. doi: 10.1007/s00228-012-1325-3. Epub 2012 Jun 17.
5
Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients.选择性 5-羟色胺再摄取抑制剂对血小板功能的影响：机制、临床结局及在老年患者中的应用意义。
Drugs Aging. 2011 May 1;28(5):345-67. doi: 10.2165/11589340-000000000-00000.
6
Serotonin transporter polymorphism and bleeding time during SSRI therapy.5-羟色胺转运体基因多态性与选择性5-羟色胺再摄取抑制剂治疗期间的出血时间
Br J Clin Pharmacol. 2008 May;65(5):761-6. doi: 10.1111/j.1365-2125.2008.03098.x. Epub 2008 Feb 12.
7
Successful anticoagulation and continuation of tramadol therapy in the setting of a tramadol-warfarin interaction.在曲马多与华法林相互作用的情况下成功进行抗凝及继续曲马多治疗。
Pharmacotherapy. 2006 Nov;26(11):1654-7. doi: 10.1592/phco.26.11.1654.
8
SSRIs and gastrointestinal bleeding.选择性5-羟色胺再摄取抑制剂与胃肠道出血
BMJ. 2005 Sep 10;331(7516):529-30. doi: 10.1136/bmj.331.7516.529.
9
Increased liability of tramadol-warfarin interaction in individuals with mutations in the cytochrome P450 2D6 gene.细胞色素P450 2D6基因突变个体中曲马多与华法林相互作用的风险增加。
Eur J Clin Pharmacol. 2004 Jul;60(5):369-72. doi: 10.1007/s00228-004-0783-7. Epub 2004 Jun 10.
10
Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.鉴定人肝微粒体中负责顺式曲马多代谢的细胞色素P-450同工酶。
Drug Metab Dispos. 2001 Aug;29(8):1146-55.