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Elife. 2016 Oct 26;5:e19799. doi: 10.7554/eLife.19799.
2
Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk.DNA修复基因APE1 Asp148Glu多态性与乳腺癌风险的关联
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3
[Genetic Polymorphisms in Wnt Signaling Pathway and Acute Leukemia].[Wnt信号通路中的基因多态性与急性白血病]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 May;46(3):403-8.
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Brain Struct Funct. 2016 Jan;221(1):433-46. doi: 10.1007/s00429-014-0916-4. Epub 2014 Oct 25.
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PLoS One. 2013;8(3):e59555. doi: 10.1371/journal.pone.0059555. Epub 2013 Mar 14.
6
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Genetic variation of CTNNB1 gene is associated with susceptibility and prognosis of gastric cancer in a Chinese population.CTNNB1 基因的遗传变异与中国人群胃癌的易感性和预后相关。
Mutagenesis. 2012 Nov;27(6):623-30. doi: 10.1093/mutage/ges027. Epub 2012 Jul 30.
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WNT信号通路中的基因变异与沙特人群的结直肠癌呈保护性关联。

Genetic variants in the WNT signaling pathway are protectively associated with colorectal cancer in a Saudi population.

作者信息

Parine Narasimha Reddy, Azzam Nahla A, Shaik Jilani, Aljebreen Abdulrahman M, Alharbi Othman, Almadi Majid A, Alanazi Mohammad, Khan Zahid

机构信息

Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Saudi J Biol Sci. 2019 Feb;26(2):286-293. doi: 10.1016/j.sjbs.2018.05.018. Epub 2018 May 17.

DOI:10.1016/j.sjbs.2018.05.018
PMID:31485167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6717108/
Abstract

The Wnt/β-catenin signaling pathway has been etiologically implicated in the development and progression of colorectal cancer. We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). Evaluation of WNT pathway SNPs showed protective association for rs4135385, located in β-catenin. Additionally, variants in SFRP3 (rs7775) and LRP6 (rs2284396) which did not show any association in the overall analysis were significantly associated with female and old aged colorectal cancer patients, respectively.

摘要

Wnt/β-连环蛋白信号通路在结直肠癌的发生和发展中具有病因学关联。我们研究了位于SFRP3（rs7775）、CTNNB1（β-连环蛋白）[rs4135385、rs13072632]、APC（rs454886、rs459552）、LRP6（rs2075241、rs2284396）、DKK4（rs3763511）、DKK3（rs6485350）、TCF4（rs12255372）和AXIN2（rs3923086、rs3923087、rs4791171）的13个单核苷酸多态性（SNP），研究对象为结直肠癌患者（n = 122）和对照组（n = 110）。对WNT通路SNP的评估显示，位于β-连环蛋白的rs4135385具有保护关联。此外，在总体分析中未显示任何关联的SFRP3（rs7775）和LRP6（rs2284396）变异，分别与女性和老年结直肠癌患者显著相关。