AXIN2 多态性与癌症风险和易感性的相关性的新见解：来自 72 项研究的证据。
New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies.
机构信息
Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
出版信息
BMC Cancer. 2021 Apr 1;21(1):353. doi: 10.1186/s12885-021-08092-0.
BACKGROUND
Numerous studies have reported the correlation between AXIN2 polymorphism and cancer risk, but the results seem not consistent. In order to get an overall, accurate and updated results about AXIN2 polymorphism and cancer risk, we conducted this study.
METHODS
An updated analysis was performed to analyze the correlation between AXIN2 polymorphisms and cancer risk. Linkage disequilibrium (LD) analysis was also used to show the associations.
RESULTS
Seventy-two case-control studies were involved in the study, including 22,087 cases and 18,846 controls. The overall results showed rs11079571 had significant association with cancer risk (allele contrast model: OR = 0.539, 95%CI = 0.478-0.609, PAdjust = 0.025; homozygote model: OR = 0.22, 95% CI = 0.164-0.295, PAdjust< 0.001; heterozygote model: OR = 0.292, 95% CI = 0.216-0.394, PAdjust< 0.001; dominant model: OR = 0.249, 95% CI = 0.189-0.33, PAdjust< 0.001). The same results were obtained with rs1133683 in homozygote and recessive models (PAdjust< 0.05), and in rs35285779 in heterozygote and dominant models (PAdjust< 0.05). LD analysis revealed significant correlation between rs7210356 and rs9915936 in the populations of CEU, CHB&CHS, ESN and JPT (CEU: r = 0.91; CHB&CHS: r = 0.74; ESN: r = 0.62, JPT: r = 0.57), and a significant correlation between rs9915936 and rs7224837 in the populations of CHB&CHS, ESN and JPT (r>0.5), between rs7224837 and rs7210356 in the populations of CEU, CHB&CHS, JPT (r>0.5), between rs35435678 and rs35285779 in the populations of CEU, CHB&CHS and JPT (r>0.5).
CONCLUSIONS
AXIN2 rs11079571, rs1133683 and rs35285779 polymorphisms have significant correlations with overall cancer risk. What's more, two or more polymorphisms such as rs7210356 and rs9915936, rs9915936 and rs7224837, rs7224837 and rs7210356, rs35435678 and rs35285779 have significant correlation with cancer susceptibility in different populations.
背景
许多研究报告了 AXIN2 多态性与癌症风险之间的相关性，但结果似乎不一致。为了获得关于 AXIN2 多态性与癌症风险的全面、准确和最新的结果，我们进行了这项研究。
方法
对 AXIN2 多态性与癌症风险的相关性进行了更新的分析。还进行了连锁不平衡（LD）分析以显示相关性。
结果
这项研究共纳入了 72 项病例对照研究，包括 22087 例病例和 18846 例对照。总体结果表明 rs11079571 与癌症风险显著相关（等位基因对比模型：OR=0.539，95%CI=0.478-0.609，PAdjust=0.025；纯合子模型：OR=0.22，95%CI=0.164-0.295，PAdjust<0.001；杂合子模型：OR=0.292，95%CI=0.216-0.394，PAdjust<0.001；显性模型：OR=0.249，95%CI=0.189-0.33，PAdjust<0.001）。在 rs1133683 的纯合子和隐性模型（PAdjust<0.05）以及 rs35285779 的杂合子和显性模型（PAdjust<0.05）中也得到了相同的结果。LD 分析显示，rs7210356 与 rs9915936 之间在 CEU、CHB&CHS、ESN 和 JPT 人群中存在显著相关性（CEU：r=0.91；CHB&CHS：r=0.74；ESN：r=0.62，JPT：r=0.57），rs9915936 与 rs7224837 之间在 CHB&CHS、ESN 和 JPT 人群中存在显著相关性（r>0.5），rs7224837 与 rs7210356 之间在 CEU、CHB&CHS、JPT 人群中存在显著相关性（r>0.5），rs35435678 与 rs35285779 之间在 CEU、CHB&CHS 和 JPT 人群中存在显著相关性（r>0.5）。
结论
AXIN2 rs11079571、rs1133683 和 rs35285779 多态性与总体癌症风险显著相关。此外，rs7210356 和 rs9915936、rs9915936 和 rs7224837、rs7224837 和 rs7210356 等两个或更多多态性与不同人群的癌症易感性存在显著相关性。
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