Balodis Iris M, Linnet Jakob, Arshad Fiza, Worhunsky Patrick D, Stevens Michael C, Pearlson Godfrey D, Potenza Marc N
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Peter Boris Centre for Addiction Research, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Int Gambl Stud. 2018;18(2):269-285. doi: 10.1080/14459795.2018.1469658. Epub 2018 Jun 5.
Neuroimaging studies demonstrate alterations in fronto-striatal neurocircuitry in gambling disorder (GD) during anticipatory processing, which may influence decision-making impairments. However, to date little is known about fronto-striatal anticipatory processing and emotion-based decision-making. While undergoing neuroimaging, 28 GD and 28 healthy control (HC) participants performed the Monetary Incentive Delay Task (MIDT). Pearson correlation coefficients assessed out-of-scanner Iowa Gambling Task (IGT) performance with the neural activity during prospect (A1) processing on the MIDT across combined GD and HC groups. The HC and GD groups showed no significant difference in out-of-scanner IGT performance, although there was a trend for higher IGT scores in the HC group on the last two IGT trial blocks. Whole-brain correlations across combined HC and GD groups showed that MIDT BOLD signal in the ventral striatum/caudate/ventromedial prefrontal cortex and anterior cingulate regions during the prospect of winning positively correlated with total IGT scores. The GD group also contained a higher proportion of tobacco smokers, and correlations between neural activations in prospect on the MIDT may relate in part to gambling and/or smoking pathology. In this study, fronto-striatal activity during the prospect of reward and loss on the MIDT was related to decision-making on the IGT, with blunted activation linked to disadvantageous decision-making. The findings from this work are novel in linking brain activity during a prospect-of-reward phase with performance on a decision-making task in individuals with and without GD.
神经影像学研究表明，在预期加工过程中，赌博障碍（GD）患者的额纹状体神经回路会发生改变，这可能会影响决策障碍。然而，迄今为止，对于额纹状体预期加工和基于情绪的决策知之甚少。在接受神经影像学检查时，28名GD患者和28名健康对照（HC）参与者完成了金钱激励延迟任务（MIDT）。皮尔逊相关系数评估了在MIDT的预期（A1）加工过程中，联合GD组和HC组的神经活动与扫描仪外爱荷华赌博任务（IGT）表现之间的关系。HC组和GD组在扫描仪外IGT表现上没有显著差异，尽管在IGT的最后两个试验块中，HC组有IGT得分更高的趋势。联合HC组和GD组的全脑相关性分析表明，在获胜预期期间，腹侧纹状体/尾状核/腹内侧前额叶皮层和前扣带区域的MIDT血氧水平依赖（BOLD）信号与IGT总得分呈正相关。GD组中吸烟者的比例也更高，MIDT预期中的神经激活之间的相关性可能部分与赌博和/或吸烟病理有关。在这项研究中，MIDT中奖励和损失预期期间的额纹状体活动与IGT上的决策有关，激活减弱与不利决策有关。这项工作的发现具有创新性，它将奖励预期阶段的大脑活动与有或无GD个体的决策任务表现联系起来。
