CTLA-4 与 PLR 联合分析对食管鳞癌（ESCC）患者的预后价值。
Prognostic Value of Combined Analysis of CTLA-4 and PLR in Esophageal Squamous Cell Carcinoma (ESCC) Patients.
机构信息
Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, 750004 Ningxia, China.
Department of Radiation Oncology, General Hospital of Chinese Armed Police Force Border Defence Force, Shenzhen, 518000 Guangdong, China.
出版信息
Dis Markers. 2019 Aug 14;2019:1601072. doi: 10.1155/2019/1601072. eCollection 2019.
OBJECTIVE
The purpose of this study was to evaluate the prognostic role of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) expression level and the platelet lymphocyte ratio (PLR) level in esophageal squamous cell carcinoma (ESCC) patients.
METHODS
84 ESCC patients who received surgical treatment in our hospital were enrolled in the study. The correlation of each biomarker's level with ESCC patients' clinicopathological characteristics and overall survival (OS) was assessed.
RESULTS
The elevated expression rate of T-CTLA-4 (tumor cell CTLA-4) and I-CTLA-4 (interstitial lymphocyte CTLA-4) was 48.8% and 44.0%, respectively. The number of enrolled patients with a higher PLR level (≥119) was 48. The prognostic value of T-CTLA-4, I-CTLA-4, and PLR in ESCC patients was not detected. However, patients with both a low T-CTLA-4 expression level and a low PLR level that had longer OS ( = 0.023) were found. The prognostic role of T-CTLA-4(-) +PLR (-) status in ESCC patients was also confirmed in multivariate analyses ( = 0.027).
CONCLUSION
These results demonstrated the potential prognostic value of combined analysis of CTLA-4 and PLR in ESCC patients.
目的
本研究旨在评估细胞毒性 T 淋巴细胞相关抗原-4（CTLA-4）表达水平和血小板淋巴细胞比值（PLR）水平在食管鳞癌（ESCC）患者中的预后作用。
方法
纳入 84 例在我院接受手术治疗的 ESCC 患者，评估每个生物标志物的水平与 ESCC 患者临床病理特征和总生存期（OS）的相关性。
结果
T-CTLA-4（肿瘤细胞 CTLA-4）和 I-CTLA-4（间质淋巴细胞 CTLA-4）的升高表达率分别为 48.8%和 44.0%。高 PLR 水平（≥119）患者的纳入人数为 48 人。T-CTLA-4、I-CTLA-4 和 PLR 对 ESCC 患者的预后价值未被检测到。然而，T-CTLA-4 表达水平低和 PLR 水平低的患者 OS 更长（=0.023）。多因素分析也证实了 T-CTLA-4(-) +PLR(-) 状态在 ESCC 患者中的预后作用（=0.027）。
结论
这些结果表明联合分析 CTLA-4 和 PLR 对 ESCC 患者具有潜在的预后价值。
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