Bergh A, Damber J E
Department of Pathology, University of Umeå, Sweden.
Int J Androl. 1988 Oct;11(5):449-56. doi: 10.1111/j.1365-2605.1988.tb01017.x.
Treatment of adult mice with 1 microgram of an LHRH-agonist or with 5 i.u. hCG, subcutaneously, resulted in an increase in the permeability to intravenously injected Evans blue into the testicular interstitial space and in the volume of testicular interstitial fluid. These changes are probably related to an increase in vascular permeability but, in contrast to the situation in rats, this was accompanied neither by an accumulation of polymorphonuclear leucocytes in testicular blood vessels nor by the formation of large inter-endothelial cell gaps in postcapillary venules. The mechanisms mediating the gonadotrophin-induced increase in vascular permeability in the mouse testis thus remain unknown.
给成年小鼠皮下注射1微克促黄体生成素释放激素（LHRH）激动剂或5国际单位人绒毛膜促性腺激素（hCG），会导致静脉注射的伊文思蓝进入睾丸间质间隙的通透性增加，以及睾丸间质液体积增加。这些变化可能与血管通透性增加有关，但与大鼠的情况不同，这既不伴有多形核白细胞在睾丸血管中的积聚，也不伴有毛细血管后微静脉内皮细胞间大间隙的形成。因此，介导促性腺激素诱导的小鼠睾丸血管通透性增加的机制仍然未知。
