Widmark A, Bergh A, Damber J E, Smedegård G
Department of Physiology, University of Umeå, Sweden.
Mol Cell Endocrinol. 1987 Sep;53(1-2):25-31. doi: 10.1016/0303-7207(87)90188-2.
Human chorionic gonadotrophin (hCG) treatment of adult male rats induces microvascular changes in the testis consisting of abolished vasomotion, an accumulation of leucocytes in postcapillary venules and increased vascular permeability. To study the role of leucocytes, rats were made leucopenic with a specific antineutrophil serum (ANS). Testicular interstitial fluid volume was decreased in leucopenic rats. Leucopenic rats also failed to show an hCG-induced increase in venular permeability as in saline-treated rats. The normally pulsatile blood flow pattern (vasomotion) persisted in leucopenic rats but was abolished after hCG treatment both in saline-treated and leucopenic rats. Plasma testosterone concentration after hCG treatment was not affected by elimination of circulating polymorphonuclear (PMN) leucocytes. It is concluded that PMN leucocytes mediate in part the hCG-induced increase in testicular venular permeability but not the hCG-induced inhibition of vasomotion.
用人类绒毛膜促性腺激素（hCG）处理成年雄性大鼠会诱发睾丸微血管变化，包括血管舒缩运动消失、毛细血管后微静脉中白细胞积聚以及血管通透性增加。为研究白细胞的作用，用特异性抗中性粒细胞血清（ANS）使大鼠白细胞减少。白细胞减少的大鼠睾丸间质液体积减少。白细胞减少的大鼠也未像生理盐水处理的大鼠那样出现hCG诱导的微静脉通透性增加。白细胞减少的大鼠中正常的搏动性血流模式（血管舒缩运动）持续存在，但在生理盐水处理组和白细胞减少组大鼠中，hCG处理后该模式均消失。hCG处理后血浆睾酮浓度不受循环多形核（PMN）白细胞清除的影响。结论是，PMN白细胞部分介导了hCG诱导的睾丸微静脉通透性增加，但不介导hCG诱导的血管舒缩运动抑制。
