溶瘤病毒疗法简介。
Introduction to Oncolytic Virotherapy.
作者信息
Engeland Christine E, Bell John C
机构信息
Research Group Mechanisms of Oncolytic Immunotherapy, Clinical Cooperation Unit Virotherapy, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), University Hospital Heidelberg, Heidelberg, Germany.
Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
出版信息
Methods Mol Biol. 2020;2058:1-6. doi: 10.1007/978-1-4939-9794-7_1.
Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor microenvironment and in situ vaccination effects. Diverse virus platforms have been developed as oncolytic vectors and designed for improved tumor specificity, intratumoral spread, therapeutic gene delivery and especially as targeted cancer immunotherapeutics. This chapter provides a concise overview of the basic principles as well as current progress in preclinical and clinical studies of oncolytic virotherapy.
溶瘤病毒利用癌症的关键特征在恶性细胞中进行复制，导致肿瘤细胞裂解、调节肿瘤微环境并产生原位疫苗效应。多种病毒平台已被开发为溶瘤载体，并设计用于提高肿瘤特异性、瘤内传播、治疗性基因递送，特别是作为靶向癌症免疫疗法。本章简要概述了溶瘤病毒疗法的基本原理以及临床前和临床研究的当前进展。
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