Applied Virology Research Center, Baqiyatallah University of Medical sciences, Tehran, Iran.
Students Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Cell Commun Signal. 2023 Sep 4;21(1):228. doi: 10.1186/s12964-023-01232-y.
Mesenchymal stem cells (MSCs) have attracted considerable interest as a promising approach for cancer treatment due to their ability to undergo tumor-trophic migration. MSCs possess the unique ability to selectively migrate to tumors, making them an excellent candidate for targeted delivery of oncolytic viruses (OVs) to treat isolated tumors and metastatic malignancies. OVs have attracted attention as a potential treatment for cancer due to their ability to selectively infect and destroy tumor cells while sparing normal cells. In addition, OVs can induce immunogenic cell death and contain curative transgenes in their genome, making them an attractive candidate for cancer treatment in combination with immunotherapies. In combination with MSCs, OVs can modulate the tumor microenvironment and trigger anti-tumor immune responses, making MSC-releasing OVs a promising approach for cancer treatment. This study reviews researches on the use of MSC-released OVs as a novel method for treating cancer. Video Abstract.
间充质干细胞（MSCs）因其能够进行肿瘤营养性迁移而引起了人们的极大兴趣，是一种有前途的癌症治疗方法。MSCs 具有选择性迁移到肿瘤的独特能力，使其成为肿瘤靶向递送溶瘤病毒（OVs）的理想候选物，以治疗孤立性肿瘤和转移性恶性肿瘤。OVs 因其能够选择性感染和破坏肿瘤细胞而不损伤正常细胞而受到关注，是一种有前途的癌症治疗方法。此外，OVs 可以诱导免疫原性细胞死亡并在其基因组中包含治疗性转基因，使其成为与免疫疗法联合治疗癌症的有吸引力的候选物。与 MSCs 联合使用时，OVs 可以调节肿瘤微环境并引发抗肿瘤免疫反应，使 MSC 释放的 OVs 成为癌症治疗的一种有前途的方法。本研究综述了 MSC 释放的 OVs 作为治疗癌症的新方法的研究。视频摘要。
