Radiation, hyperthermia, and their combination in treatment of chemically induced autochthonous tumors in mice.

All autochthonous tumors induced chemically in the thighs of C3H/He mice showed recurrence after single X-irradiation with 20-60 Gy when they were 10 mm in diameter, although this treatment caused temporary, dose-dependent regression. Hyperthermia for 30 min at 43.0 degrees alone had little effect. However, in 2 of 16 mice, hyperthermia after irradiation at 60 Gy resulted in complete cure, i.e., survival of mice without recurrence for more than 120 days after treatment. These results indicate that the combined treatment of radiation and hyperthermia is necessary to obtain the cure of mouse autochthonous tumors.