Sato S, Ootsuyama A, Tanooka H
Department of Radiology, Toho University Oohashi Hospital, Tokyo.
Jpn J Cancer Res. 1988 Dec;79(12):1359-63. doi: 10.1111/j.1349-7006.1988.tb01567.x.
All autochthonous tumors induced chemically in the thighs of C3H/He mice showed recurrence after single X-irradiation with 20-60 Gy when they were 10 mm in diameter, although this treatment caused temporary, dose-dependent regression. Hyperthermia for 30 min at 43.0 degrees alone had little effect. However, in 2 of 16 mice, hyperthermia after irradiation at 60 Gy resulted in complete cure, i.e., survival of mice without recurrence for more than 120 days after treatment. These results indicate that the combined treatment of radiation and hyperthermia is necessary to obtain the cure of mouse autochthonous tumors.
在C3H/He小鼠大腿部化学诱导产生的所有自发性肿瘤,当直径达到10毫米时,经20 - 60 Gy单次X线照射后均出现复发,尽管这种治疗会导致肿瘤暂时出现剂量依赖性退缩。单独在43.0摄氏度进行30分钟的热疗效果甚微。然而,在16只小鼠中有2只,60 Gy照射后进行热疗实现了完全治愈,即治疗后小鼠存活且无复发超过120天。这些结果表明,联合放疗和热疗对于治愈小鼠自发性肿瘤是必要的。