维生素 D 作为雪旺氏膜切开后坐骨神经缺血性轴突再生的潜在药物。
Vitamin D as a Potential Agent for Ischemic Axonal Regeneration after Epineurial Devascularization of the Sciatic Nerve.
机构信息
Department of Anatomy, Cukurova University, Faculty of Medicine, Adana, Turkey.
Department of Anatomy, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
出版信息
Curr Neurovasc Res. 2019;16(4):392-401. doi: 10.2174/1567202616666190905160229.
BACKGROUND
Although vitamin D has several noncalcemic functions particularly on nervous system, its neuroregenerative roles on ischemic peripheral nerve injury has not been reported. In this study, it was aimed to investigate the effect of vitamin D3 after epineurial devascularization of the sciatic nerve.
METHODS
Forty adult female Wistar rats were randomly divided into four groups: Group 1 (Control), Group 2 (Sham-operated), Group 3 (Epineurial devascularization + vitamin D3 treatment), Group 4 (Epineurial devascularization + vehicle treatment). Recovery of the sciatic nerve was analyzed by functional (sciatic functional index, pinch test and biochemical analyses) and morphological (electron microscopic analysis and wet muscle weight analysis) methods.
RESULTS
Comparison of the data revealed that vitamin D3 administration had a beneficial effect on regeneration after epineurial devascularization.
CONCLUSION
We suggest that vitamin D3 is an effective agent in the prevention of ischemic peripheral nerve insults.
背景
尽管维生素 D 具有多种非钙调功能，特别是在神经系统方面，但它在缺血性周围神经损伤中的神经再生作用尚未得到报道。在这项研究中，我们旨在研究维生素 D3 对坐骨神经外膜去血管化后的影响。
方法
40 只成年雌性 Wistar 大鼠随机分为四组：第 1 组（对照组）、第 2 组（假手术组）、第 3 组（外膜去血管化+维生素 D3 治疗组）、第 4 组（外膜去血管化+载体治疗组）。通过功能（坐骨神经功能指数、捏压试验和生化分析）和形态学（电镜分析和湿肌肉重量分析）方法分析坐骨神经的恢复情况。
结果
数据比较表明，维生素 D3 给药对外膜去血管化后的再生有有益影响。
结论
我们认为维生素 D3 是预防缺血性周围神经损伤的有效药物。
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