汗腺干细胞的异质性。

Heterogeneity of Sweat Gland Stem Cells.

机构信息

Fraunhofer Research Institution for Marine Biotechnology and Cell Technology, Lübeck, Germany.

Institute of Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany.

出版信息

Adv Exp Med Biol. 2019;1169:55-62. doi: 10.1007/978-3-030-24108-7_3.

DOI:10.1007/978-3-030-24108-7_3

PMID:31487018

Abstract

Sweat glands play an important role in skin physiology and are an integral part of the natural skin barrier. In order to maintain functionality throughout life, sweat glands make use of several types of stem cells. This chapter focuses on the classification of different types of stem cells found in the sweat gland and their physiological roles. First, sweat gland formation during skin maturation is addressed in order to give an overview of sweat gland origin and formation in vivo. Then, different kinds of adult sweat gland stem cells are introduced and classified between different potency levels and corresponding physiological roles. Finally, the importance of these cell sources for future developments, including applications in wound healing and cosmetics research, is discussed.

摘要

汗腺在皮肤生理学中起着重要作用，是天然皮肤屏障的组成部分。为了在整个生命周期内保持功能，汗腺利用多种类型的干细胞。本章重点介绍了在汗腺中发现的不同类型的干细胞及其生理作用的分类。首先，讨论了皮肤成熟过程中的汗腺形成，以概述体内汗腺的起源和形成。然后，介绍了不同类型的成人汗腺干细胞，并根据不同的潜能水平和相应的生理作用进行分类。最后，讨论了这些细胞来源对未来发展的重要性，包括在伤口愈合和化妆品研究中的应用。