Zhang J J, Wang M Y, Zhao J, Jiang D Y
The Second Clinical College, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Department of Emergency, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Mar 20;38(3):296-300. doi: 10.3760/cma.j.cn501120-20210123-00033.
Sweat gland is one of the important appendage organs of the skin, which plays an important role in thermoregulation and homeostasis maintenance. Sweat glands are damaged and unable to self-repair after burns, resulting in perspiration disorders eventually. However, current clinical strategies cannot restore the function of the damaged sweat glands effectively. Therefore, it is urgent to seek treatments that can promote the regeneration of sweat glands and restore their normal functions. Stem cells have extensive sources, low immunogenicity, high proliferation capacity, and multi-directional differentiation potential, which have become a focus in the field of regenerative medicine. In recent years, a variety of stem cells have been induced to differentiate into sweat gland-like tissue with certain secretory function, which provides treatment direction for sweat gland regeneration after burns in clinic. This article reviews the recent research advances on the application of stem cells in sweat gland regeneration from the perspectives of the manner by which stem cells transform into sweat gland cells in different environments and their influencing factors.
汗腺是皮肤重要的附属器官之一，在体温调节和维持体内稳态中发挥着重要作用。烧伤后汗腺受损且无法自我修复，最终导致出汗障碍。然而，目前的临床策略无法有效恢复受损汗腺的功能。因此，迫切需要寻找能够促进汗腺再生并恢复其正常功能的治疗方法。干细胞来源广泛、免疫原性低、增殖能力强且具有多向分化潜能，已成为再生医学领域的一个研究热点。近年来，多种干细胞已被诱导分化为具有一定分泌功能的汗腺样组织，这为临床上烧伤后汗腺再生提供了治疗方向。本文从不同环境下干细胞向汗腺细胞转化的方式及其影响因素等方面，综述了干细胞在汗腺再生应用中的最新研究进展。
