Borsuk P, Gniadkowski M, Bartnik E, Stepień P P
Department of Genetics, University of Warsaw, Poland.
J Mol Evol. 1988;28(1-2):125-30. doi: 10.1007/BF02143503.
All Aspergillus nidulans 5S rRNA pseudogenes known so far are the result of integration of an approx. 0.2-kbp-long DNA sequence into the 5S rRNA genes. This sequence, called block C, is present in at least five copies in the A. nidulans genome and seems to be associated either with 5S rRNA genes or pseudogenes. In contrast to the 78% sequence conservation of the C-block in pseudogenes, the truncated 5' halves of the pseudogenes are very highly conserved (96.9-100%). We postulate that the 5S rRNA pseudogenes are still a subject of concerted evolution. The C-block sequence shows similarity to the switch region of the mouse heavy chain immunoglobulin gene. A characteristic motif GGGTGAG is repeated several times in both sequences; the sequence conservation is 63%.
目前已知的所有构巢曲霉5S rRNA假基因都是一段约0.2千碱基对长的DNA序列整合到5S rRNA基因中的结果。这个序列被称为C区，在构巢曲霉基因组中至少有五个拷贝，似乎与5S rRNA基因或假基因相关。与假基因中C区78%的序列保守性不同，假基因截短的5'端非常高度保守（96.9 - 100%）。我们推测5S rRNA假基因仍然是协同进化的对象。C区序列与小鼠重链免疫球蛋白基因的转换区相似。一个特征基序GGGTGAG在两个序列中都重复了几次；序列保守性为63%。
