Department of Gynecology Surgery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Am J Reprod Immunol. 2012 Oct;68(4):338-44. doi: 10.1111/j.1600-0897.2012.01167.x. Epub 2012 Jun 28.
Pre-term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL12 (SDF-1) and CXCL10 (IP-10) in cord blood of term and pre-term delivered fetuses and their corresponding mothers.
Cord and peripheral blood samples were collected from 50 pre-term and 50 term infants and their mothers. Serum levels of CXCL12 and CXCL10 were measured by ELISA.
The findings of this study indicated that the circulating levels of CXCL10 were elevated in mothers bearing pre-term infants, while CXCL12 was only increased in pre-term infants.
The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre-term labor, which probably is controlled by inducible chemokines such as CXCL10.
早产是一种在全球范围内尚未被充分了解的常见疾病。本研究旨在探讨足月和早产胎儿及其相应母亲脐带血中趋化因子 CXCL12（基质细胞衍生因子 1，SDF-1）和 CXCL10（干扰素诱导蛋白 10，IP-10）的循环水平。
采集了 50 例早产儿和 50 例足月产婴儿及其母亲的脐带和外周血样本。采用 ELISA 法检测血清中 CXCL12 和 CXCL10 的水平。
本研究结果表明，携带早产儿的母亲血清中 CXCL10 的循环水平升高，而 CXCL12 仅在早产儿中升高。
这些发现表明，母亲和婴儿的病理生理状态都与早产有关。此外，这些发现提示早产分娩中存在炎症反应，可能由诱导型趋化因子如 CXCL10 控制。
Zotero 插件