Department of Endocrinology and Metabolism, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Horm Metab Res. 2019 Oct;51(10):649-654. doi: 10.1055/a-0998-4079. Epub 2019 Sep 5.
The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with acromegaly (37 females and 17 males) and 34 healthy controls (22 females and 12 males). Serum visfatin was measured by ELISA. Acromegalic and control participants and those with active or controlled acromegaly were compared with respect to their serum visfatin, clinical and metabolic parameters, EFT, cIMT, and ABI. Linear correlation was used to identify associations between these parameters and visfatin in all participants. Serum visfatin and glycated hemoglobin (HbA1c) were higher in the acromegaly group than in the control group (p0.001 and p0.007, respectively). There was no difference in visfatin between the active and controlled acromegaly groups, but HbA1c was higher in the active than the controlled acromegaly group (p<0.04). EFT, cIMT, and ABI were similar between the acromegaly and control groups and between the active and controlled acromegaly groups. Serum visfatin positively correlated with HbA1c, growth hormone (GH), and insulin-like growth factor-1 (IGF-1)/upper limit of normal ratio (r=0.245, p=0.024; r=0.259, p=0.017; and r=0.282, p=0.009, respectively). This study has revealed that a high visfatin level is associated with glycemic dysregulation and higher levels of GH and IGF-1 in acromegalic patients.
本研究旨在比较肢端肥大症患者与健康对照者的血清内脂素水平，并评估内脂素水平与心外膜脂肪厚度（EFT）、颈动脉内膜中层厚度（cIMT）和踝臂指数（ABI）之间的关系。我们进行了一项横断面病例对照研究，纳入了 54 例肢端肥大症患者（37 名女性和 17 名男性）和 34 名健康对照者（22 名女性和 12 名男性）。采用 ELISA 法检测血清内脂素水平。比较肢端肥大症患者和对照组、活动期和控制期肢端肥大症患者的血清内脂素、临床和代谢参数、EFT、cIMT 和 ABI。采用线性相关分析所有参与者中这些参数与内脂素的相关性。肢端肥大症组血清内脂素和糖化血红蛋白（HbA1c）水平高于对照组（p0.001 和 p0.007）。活动期和控制期肢端肥大症患者的内脂素水平无差异，但活动期患者的 HbA1c 高于控制期患者（p<0.04）。肢端肥大症组和对照组、活动期和控制期肢端肥大症患者的 EFT、cIMT 和 ABI 无差异。血清内脂素与 HbA1c、生长激素（GH）和胰岛素样生长因子-1（IGF-1）/正常上限比值呈正相关（r=0.245，p=0.024；r=0.259，p=0.017；r=0.282，p=0.009）。本研究表明，肢端肥大症患者中高内脂素水平与血糖调节紊乱以及 GH 和 IGF-1 水平升高有关。
