Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Tepecik Training and Research Hospital, Tepecik, 35120, Izmir, Turkey.
Hormones (Athens). 2019 Dec;18(4):435-442. doi: 10.1007/s42000-019-00151-3. Epub 2019 Nov 6.
Irisin, a peptide secreted from muscle and adipose tissues, is associated with insulin resistance as well as metabolic and cardiovascular diseases. Acromegaly is a rare disorder caused by overproduction of growth hormone (GH) and is associated with functional and structural differentiation of adipose and muscle tissues. Acromegalic subjects are also at risk of vascular diseases and metabolic dysfunctions. We aimed to determine the altered levels of irisin in subjects with active acromegaly and controlled acromegaly and in controls, and to ascertain whether there is an association between irisin and hormonal and cardiometabolic parameters.
We enrolled 40 subjects with active acromegaly, 30 subjects with controlled acromegaly, and 40 control subjects of matched age, gender, BMI, and occurrence of hypertension, diabetes, and metabolic syndrome distribution in the present cross-sectional study. Hormonal and metabolic parameters, carotid intima media thickness (cIMT), and epicardial fat thickness (EFT) of the subjects were evaluated. Irisin levels were measured using ELISA.
Circulating levels of irisin were significantly higher in acromegalic subjects compared to both controlled acromegalic subjects and controls. Moreover, irisin levels were elevated in controlled acromegalic subjects compared to controls. Irisin displayed a positive correlation with insulin resistance, cIMT, EFT, BMI, GH, and insulin-like growth factor (IGF-1) in acromegalic subjects. Irisin levels were independently associated with cIMT and EFT according to multiple regression analyses. There was an independent relationship between irisin and IGF-1.
Elevated irisin levels in acromegalic subjects were associated with cIMT and EFT, suggesting that irisin is a surrogate marker for cardiovascular risk in acromegalic subjects.
鸢尾素是一种由肌肉和脂肪组织分泌的肽，与胰岛素抵抗以及代谢和心血管疾病有关。肢端肥大症是一种由生长激素（GH）过度产生引起的罕见疾病，与脂肪和肌肉组织的功能和结构分化有关。肢端肥大症患者也有发生血管疾病和代谢功能障碍的风险。我们旨在确定活跃型肢端肥大症、控制型肢端肥大症和对照组患者中鸢尾素的改变水平，并确定鸢尾素与激素和心脏代谢参数之间是否存在关联。
我们在这项横断面研究中纳入了 40 名活跃型肢端肥大症患者、30 名控制型肢端肥大症患者和 40 名年龄、性别、BMI 匹配且高血压、糖尿病和代谢综合征发生率相同的对照组患者。评估了受试者的激素和代谢参数、颈动脉内膜中层厚度（cIMT）和心外膜脂肪厚度（EFT）。使用 ELISA 法测量鸢尾素水平。
与控制型肢端肥大症患者和对照组相比，肢端肥大症患者的循环鸢尾素水平显著升高。此外，控制型肢端肥大症患者的鸢尾素水平高于对照组。在肢端肥大症患者中，鸢尾素与胰岛素抵抗、cIMT、EFT、BMI、GH 和胰岛素样生长因子（IGF-1）呈正相关。根据多元回归分析，鸢尾素水平与 cIMT 和 EFT 独立相关。鸢尾素与 IGF-1 之间存在独立关系。
肢端肥大症患者中升高的鸢尾素水平与 cIMT 和 EFT 相关，表明鸢尾素是肢端肥大症患者心血管风险的替代标志物。
