Jin Zhengyang, Wei Suiyan, Jin Wenyang, Lu Bingheng, Xu Yan
School of Mechanical Engineering, Xinjiang University, Urumchi 830017, China.
The First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, China.
Polymers (Basel). 2024 Jul 8;16(13):1952. doi: 10.3390/polym16131952.
This study aimed to develop Janus-, cross-network-, and coaxial-structured piezoelectric-conductive polymer nanofibers through electrospinning to mimic the piezoelectricity of bone and facilitate the conduction of electrical signals in bone tissue repair. These nanofibers were constructed using the piezoelectric polymer polyvinylidene fluoride, and the conductive fillers reduced graphene oxide and polypyrrole. The influence of structural features on the electroactivity of the fibers was also explored. The morphology and components of the various structural samples were characterized using SEM, TEM, and FTIR. The electroactivity of the materials was assessed with a quasi-static d33 meter and the four-probe method. The results revealed that the piezoelectric-conductive phases were successfully integrated. The Janus-structured nanofibers demonstrated the best electroactivity, with a piezoelectric constant d33 of 24.5 pC/N and conductivity of 6.78 × 10 S/m. The tensile tests and MIP measurements showed that all samples had porosity levels exceeding 70%. The tensile strength of the Janus and cross-network structures exceeded that of the periosteum (3-4 MPa), with average pore sizes of 1194.36 and 2264.46 nm, respectively. These properties indicated good mechanical performance, allowing material support while preventing fibroblast invasion. The CCK-8 and ALP tests indicated that the Janus-structured samples were biocompatible and significantly promoted the proliferation of MC3T3-E1 cells.
本研究旨在通过静电纺丝制备具有双面、交联网络和同轴结构的压电导电聚合物纳米纤维，以模拟骨的压电性，并促进骨组织修复中电信号的传导。这些纳米纤维采用压电聚合物聚偏氟乙烯构建，导电填料为还原氧化石墨烯和聚吡咯。还探讨了结构特征对纤维电活性的影响。使用扫描电子显微镜（SEM）、透射电子显微镜（TEM）和傅里叶变换红外光谱（FTIR）对各种结构样品的形态和成分进行了表征。用准静态d33仪和四探针法评估了材料的电活性。结果表明，压电导电相成功整合。双面结构的纳米纤维表现出最佳的电活性，压电常数d33为24.5 pC/N，电导率为6.78×10 S/m。拉伸试验和MIP测量表明，所有样品的孔隙率均超过70%。双面和交联网络结构的拉伸强度超过骨膜（3-4 MPa），平均孔径分别为1194.36和2264.46 nm。这些性能表明其具有良好的力学性能，在防止成纤维细胞侵入的同时能够提供材料支撑。CCK-8和碱性磷酸酶（ALP）测试表明，双面结构样品具有生物相容性，并显著促进了MC3T3-E1细胞的增殖。
